Accession
MI0000076
Symbol
HGNC:
MIR20A
Description
Homo sapiens
hsa-mir-20a precursor miRNA mir-17
Gene
family?
family?
RF00051;
mir-17
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR20A is a microRNA that has been implicated in various cellular processes, including the regulation of apoptosis proteins and the modulation of cellular proliferation and migration in the context of cancer [PMC6912041]. Research has shown that atelocollagen-based gene-activated matrices (GAM) containing plasmid DNAs encoding MIR20A (pMIR20A) can be used to enhance cranial bone augmentation in rats, a model relevant to regenerative therapy for jawbone atrophy [PMC7955717]. The expression levels of MIR20A, along with other microRNAs, can be quantified using RT-PCR techniques to assess their relative abundance in different experimental groups [PMC9687337]. Interestingly, the upregulation of SNHG5 has been found to decrease MIR20A levels, which subsequently leads to an increase in apoptosis-related proteins such as BECN1, ATG5, and ATG7 and affects the autophagic process as indicated by LC3‐II/LC3‐I ratios [PMC6912041]. Preliminary experiments have also indicated that atelocollagen-based delivery systems for MIR20A are highly efficient and non-toxic for transfection into cultured mesenchymal stem cells (MSCs), offering an advantage over traditional commercial vectors like lentiviral vectors [PMC7955717].
Literature search
463 open access papers mention hsa-mir-20a
(1949 sentences)
(1949 sentences)
Sequence
992364
reads,
6826
reads per million, 155 experiments
guagcacUAAAGUGCUUAUAGUGCAGGUAGuguuuaguuaucuACUGCAUUAUGAGCACUUAAAGuacugc
((((.(((.(((((((((((((((((.(((...........))))))))))))))))))))..))).))))
((((.(((.(((((((((((((((((.(((...........))))))))))))))))))))..))).))))
Structure
c -A G uguu
guag acU AAGUGCUUAUAGUGCAG UAG u
|||| ||| ||||||||||||||||| ||| a
cguc uGA UUCACGAGUAUUACGUC Auc g
a AA - uauu
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr13: 91351065-91351135 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-20a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-20a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-20a is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-20a is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-20a-5p
| Accession | MIMAT0000075 |
| Description | Homo sapiens hsa-miR-20a-5p mature miRNA |
| Sequence | 8 - UAAAGUGCUUAUAGUGCAGGUAG - 30 |
| Evidence |
experimental
cloned [1,4-7], Northern [1] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-20a-3p
| Accession | MIMAT0004493 |
| Description | Homo sapiens hsa-miR-20a-3p mature miRNA |
| Sequence | 44 - ACUGCAUUAUGAGCACUUAAAG - 65 |
| Evidence |
experimental
cloned [6] |
| Database links |
|
| Predicted targets |
|
References
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