Stem-loop sequence hsa-mir-16-2

Accession

MI0000115 (change log)

Previous IDs

hsa-mir-16-3

Symbol

HGNC:MIR16-2

Description

Homo sapiens miR-16-2 stem-loop

Gene family

MIPF0000006; mir-15

Literature search

682 open access papers mention hsa-mir-16-2
(3184 sentences)

Stem-loop

     uc    cu         ua        c  ag   aau 
5' gu  cacu  agcagcacg  aauauugg gu  uga   a
   ||  ||||  |||||||||  |||||||| ||  |||    
3' ca  guga  ucgucgugu  uuauaacc ca  auu   u
     gu    uu         ca        a  -a   aua 

Deep sequencing

3881017 reads, 1.04e+04 reads per million, 159 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

This entry represents a second putative hairpin precursor sequence for miR-16, located on chromosome 3 (see also MI0000070). The sequence was previously named mir-16-3 here and in references [1] and [2].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr3: 160404745-160404825 [+]
• Overlapping transcripts:

  intergenic

Clustered miRNAs

< 10kb from hsa-mir-16-2

• hsa-mir-15b: chr3: 160404588-160404685 [+]
• hsa-mir-16-2: chr3: 160404745-160404825 [+]

Database links

• EntrezGene:MIR16-2
• HGNC:MIR16-2
• RNAcentral:URS000017EE98_9606
• miRBase Tracker:MI0000115

Mature sequence hsa-miR-16-5p

• Accession: MIMAT0000069
• Previous IDs: hsa-miR-16
• Sequence: 10 - uagcagcacguaaauauuggcg - 31
• Deep sequencing: 7830515 reads, 159 experiments
• Evidence: experimental; cloned [1,3-4,6-8], Northern [3]
• Database links:
  • RNAcentral:URS00004BCD9C_9606
• Predicted targets:
  • TargetMiner:hsa-miR-16-5p
  • TargetScanVert:hsa-miR-16-5p
  • miRDB:hsa-miR-16-5p
  • microrna.org:hsa-miR-16-5p

Mature sequence hsa-miR-16-2-3p

• Accession: MIMAT0004518
• Previous IDs: hsa-miR-16-2*
• Sequence: 53 - ccaauauuacugugcugcuuua - 74
• Deep sequencing: 12590 reads, 157 experiments
• Evidence: experimental; cloned [7]
• Database links:
  • RNAcentral:URS00001E9CCB_9606
• Predicted targets:
  • TargetMiner:hsa-miR-16-2-3p
  • TargetScanVert:hsa-miR-16-2-3p
  • miRDB:hsa-miR-16-2-3p
  • microrna.org:hsa-miR-16-2-3p

References

1. PMID:11914277 "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs" Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G Genes Dev. 16:720-728(2002).
2. PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
3. PMID:11679670 "Identification of novel genes coding for small expressed RNAs" Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T Science. 294:853-858(2001).
4. PMID:15183728 "Human embryonic stem cells express a unique set of microRNAs" Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS Dev Biol. 270:488-498(2004).
5. PMID:14573789 "Reduced accumulation of specific microRNAs in colorectal neoplasia" Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ Mol Cancer Res. 1:882-891(2003).
6. PMID:15325244 "Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells" Kasashima K, Nakamura Y, Kozu T Biochem Biophys Res Commun. 322:403-410(2004).
7. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
8. PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).