Stem-loop mmu-mir-30a

Accession

MI0000144

Symbol

MGI: Mir30a

Description

Mus musculus mmu-mir-30a precursor miRNA

Literature search

231 open access papers mention mmu-mir-30a
(1596 sentences)

Sequence

4925552 reads, 5197 reads per million, 107 experiments

gcgacUGUAAACAUCCUCGACUGGAAGcugugaagccacaaaugggCUUUCAGUCGGAUGUUUGCAGCugc
(((.((((((((((((..((((((((((((((....))).....))))))))))))))))))))))).)))

Structure

   a            UC           -----   a 
gcg cUGUAAACAUCC  GACUGGAAGcu     gug a
||| ||||||||||||  |||||||||||     |||  
cgu GACGUUUGUAGG  CUGACUUUCgg     cac g
   C            --           guaaa   c 

Annotation confidence High

Comments

Landgraf et al. confirm that the 5' mature miRNA product is the predominant one [4].

Genome context

chr1: 23272269-23272339 [+]

Mature mmu-miR-30a-5p

• Accession: MIMAT0000128
• Description: Mus musculus mmu-miR-30a-5p mature miRNA
• Sequence: 6 - UGUAAACAUCCUCGACUGGAAG - 27
• Evidence: experimental ; cloned [1-2,4], Illumina [5-6]

Mature mmu-miR-30a-3p

• Accession: MIMAT0000129
• Description: Mus musculus mmu-miR-30a-3p mature miRNA
• Sequence: 47 - CUUUCAGUCGGAUGUUUGCAGC - 68
• Evidence: experimental ; cloned [1,3-4], Illumina [5-6]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


3. PubMed ID: 15538371
   A pancreatic islet-specific microRNA regulates insulin secretion
   "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
   "Nature (2004) 432:226-230


4. PubMed ID: 16766679
   Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
   "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
   "Genes Dev (2006) 20:1732-1743


5. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


6. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009