Stem-loop mmu-mir-142a

Accession

MI0000167

Description

Mus musculus mmu-mir-142a precursor miRNA mir-142

Gene
family

RF01896; mir-142

Literature search

185 open access papers mention mmu-mir-142a
(2073 sentences)

Sequence

1627958 reads, 3853.0 reads per million, 158 experiments

aCCCAUAAAGUAGAAAGCACUACUaacagcacuggagggUGUAGUGUUUCCUACUUUAUGGAUg
..(((((((((((.(((((((((...(..(....)..)..))))))))).)))))))))))...

Structure

-aC           A         Uaa ag a 
   CCAUAAAGUAG AAGCACUAC   c  c c
   ||||||||||| |||||||||   |  |  
   GGUAUUUCAUC UUUGUGAUG   g  g u
gUA           C         -Ug ga g 

Annotation confidence High

Comments

Expression of miRNAs from both 5' and 3' arms of this precursor have been independently verified in the mouse gut tissue [1] and in embryonic stem cells [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

11: 87647690-87647753 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from mmu-mir-142a

Mature mmu-miR-142a-5p

• Accession: MIMAT0000154
• Description: Mus musculus mmu-miR-142a-5p mature miRNA
• Sequence: 2 - CCCAUAAAGUAGAAAGCACUACU - 24
• Evidence: experimental ; cloned [1-3], Illumina [4-5]

Mature mmu-miR-142a-3p

• Accession: MIMAT0000155
• Description: Mus musculus mmu-miR-142a-3p mature miRNA
• Sequence: 40 - UGUAGUGUUUCCUACUUUAUGGAU - 63
• Evidence: experimental ; cloned [1-3], Illumina [4-5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12919684
   Embryonic stem cell-specific MicroRNAs
   "Houbaviy HB, Murray MF, Sharp PA"
   "Dev Cell (2003) 5:351-358


3. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


4. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


5. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009