Stem-loop sequence hsa-mir-7-3

Accession

MI0000265 (change log)

Symbol

HGNC:MIR7-3

Description

Homo sapiens miR-7-3 stem-loop

Gene family

MIPF0000022; mir-7

Literature search

335 open access papers mention hsa-mir-7-3
(2038 sentences)

Stem-loop

   agauua   u  cugu     a        u  aa a  a       u      c  au 
5'       gag gg    ggucu gugcugug gg  g cu gugauuu guuguu ug  g
         ||| ||    ||||| |||||||| ||  | || ||||||| |||||| ||   
3'       cuu cc    ucaga cgcgauac cc  c ga cacugaa caacag au  u
   ---cag   c  ----     -        u  gg c  -       -      c  ca 

Deep sequencing

1112233 reads, 3.28e+03 reads per million, 162 experiments

Confidence

Annotation confidence: not enough data

Feedback: Do you believe this miRNA is real?

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Expression in human was later verified by cloning [1,2].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr19: 4770670-4770779 [+]
• Overlapping transcripts:

  sense

  OTTHUMT00000318990 ; MIR7-3HG-001; intron 2

  OTTHUMT00000459346 ; MIR7-3HG-004; intron 2

  OTTHUMT00000459348 ; MIR7-3HG-003; intron 2

  OTTHUMT00000459350 ; MIR7-3HG-010; intron 2

  OTTHUMT00000459353 ; MIR7-3HG-006; intron 2

  OTTHUMT00000459347 ; MIR7-3HG-009; intron 3

  OTTHUMT00000459352 ; MIR7-3HG-008; intron 3

  OTTHUMT00000459345 ; MIR7-3HG-002; intron 4

  OTTHUMT00000459351 ; MIR7-3HG-005; intron 5

  ENST00000384898 ; MIR7-3-201; exon 1

  ENST00000317292 ; MIR7-3HG-001; intron 2

  ENST00000592709 ; MIR7-3HG-004; intron 2

  ENST00000589639 ; MIR7-3HG-003; intron 2

  ENST00000592663 ; MIR7-3HG-010; intron 2

  ENST00000589368 ; MIR7-3HG-006; intron 2

  ENST00000588711 ; MIR7-3HG-009; intron 3

  ENST00000588923 ; MIR7-3HG-008; intron 3

  ENST00000586721 ; MIR7-3HG-002; intron 4

  ENST00000588758 ; MIR7-3HG-005; intron 5

Database links

• EntrezGene:MIR7-3
• HGNC:MIR7-3
• RNAcentral:URS00004C38BB_9606
• Rfam:mir-7
• miRBase Tracker:MI0000265

Mature sequence hsa-miR-7-5p

• Accession: MIMAT0000252
• Previous IDs: hsa-miR-7
• Sequence: 31 - uggaagacuagugauuuuguuguu - 54
• Deep sequencing: 3423555 reads, 162 experiments
• Evidence: experimental; cloned [2-3]
• Database links:
  • RNAcentral:URS0000591950_9606
• Predicted targets:
  • TargetMiner:hsa-miR-7-5p
  • TargetScanVert:hsa-miR-7-5p
  • miRDB:hsa-miR-7-5p
  • microrna.org:hsa-miR-7-5p

References

1. PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
2. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
3. PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).