Stem-loop sequence hsa-mir-181c

Accession

MI0000271 (change log)

Symbol

HGNC:MIR181C

Description

Homo sapiens miR-181c stem-loop

Gene family

MIPF0000007; mir-181

Literature search

279 open access papers mention hsa-mir-181c
(1229 sentences)

Stem-loop

   c   -aaauuug   a  g  ug   gaa        cu       a     ggca 
5'  gga        cca gg uu  ggg   cauucaac  gucggug guuug    g
    |||        ||| || ||  |||   ||||||||  ||||||| |||||    c
3'  ccu        ggu cc ga  ccc   gugaguug  cagcuac caaac    u
   u   accguuaa   -  g  gu   -ag        -c       -     ggac 

Deep sequencing

112975 reads, 180 reads per million, 157 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm the expression of miR-181c in human [2].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr19: 13874699-13874808 [+]
• Overlapping transcripts:

  intergenic

Clustered miRNAs

< 10kb from hsa-mir-181c

• hsa-mir-181c: chr19: 13874699-13874808 [+]
• hsa-mir-181d: chr19: 13874875-13875011 [+]

Database links

• EntrezGene:MIR181C
• HGNC:MIR181C
• RNAcentral:URS0000394A9E_9606
• Rfam:mir-181
• miRBase Tracker:MI0000271

Mature sequence hsa-miR-181c-5p

• Accession: MIMAT0000258
• Previous IDs: hsa-miR-181c
• Sequence: 27 - aacauucaaccugucggugagu - 48
• Deep sequencing: 86561 reads, 157 experiments
• Evidence: experimental; cloned [2]
• Database links:
  • RNAcentral:URS000018C928_9606
• Predicted targets:
  • TargetMiner:hsa-miR-181c-5p
  • TargetScanVert:hsa-miR-181c-5p
  • miRDB:hsa-miR-181c-5p
  • microrna.org:hsa-miR-181c-5p

Mature sequence hsa-miR-181c-3p

• Accession: MIMAT0004559
• Previous IDs: hsa-miR-181c*
• Sequence: 65 - aaccaucgaccguugaguggac - 86
• Deep sequencing: 26397 reads, 153 experiments
• Evidence: experimental; cloned [2]
• Database links:
  • RNAcentral:URS0000244A71_9606
• Predicted targets:
  • TargetMiner:hsa-miR-181c-3p
  • TargetScanVert:hsa-miR-181c-3p
  • miRDB:hsa-miR-181c-3p
  • microrna.org:hsa-miR-181c-3p

References

1. PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
2. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).