Accession
MI0000284
Symbol
HGNC:
MIR204
Description
Homo sapiens
hsa-mir-204 precursor miRNA mir-204
Gene
family?
family?
RF00646;
mir-204
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR204 is a microRNA implicated in various biological processes and diseases [PMC4588317]. Research involving a PLGA delivery system-functionalized titanium showed that this system did not significantly affect cell survival and proliferation, even when a MIR204 inhibitor was used, indicating that MIR204 does not have a major impact on these cell processes in this context [PMC5627761]. Additionally, MIR204 has been identified as one of several microRNAs and histone modifications that contribute to the development of anterior segment diseases such as Primary Open Angle Glaucoma [PMC4588317]. Furthermore, there is evidence of a correlation between liver fat accumulation in the context of IDH2 deficiency and MIR204 levels when subjected to a high-fat diet, as indicated by the Pearson correlation coefficient [PMC9492679]. This suggests that MIR204 may have broader implications in metabolic processes and disease states beyond its role in ocular conditions.
Literature search
191 open access papers mention hsa-mir-204
(1578 sentences)
(1578 sentences)
Sequence
23274
reads,
816
reads per million, 110 experiments
ggcuacagucuuucuucaugugacucguggacUUCCCUUUGUCAUCCUAUGCCUgagaauauaugaaggagGCUGGGAAGGCAAAGGGACGUucaauugucaucacuggc
.....((((..........(((((...(((((.((((((((((.(((((.((((...............))))))))).)))))))))).)))))...))))).))))..
.....((((..........(((((...(((((.((((((((((.(((((.((((...............))))))))).)))))))))).)))))...))))).))))..
Structure
ggcua cuuucuucau ucg U A U gagaau
cagu gugac uggac UCCCUUUGUC UCCUA GCCU a
|||| ||||| ||||| |||||||||| ||||| |||| u
guca uacug acuUG AGGGAAACGG AGGGU CGga a
---cg ---------c uua C A - ggaagu
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2].
Genome context
chr9: 70809975-70810084 [-]
Disease association
hsa-mir-204 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-204-5p
| Accession | MIMAT0000265 |
| Description | Homo sapiens hsa-miR-204-5p mature miRNA |
| Sequence | 33 - UUCCCUUUGUCAUCCUAUGCCU - 54 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-204-3p
| Accession | MIMAT0022693 |
| Description | Homo sapiens hsa-miR-204-3p mature miRNA |
| Sequence | 72 - GCUGGGAAGGCAAAGGGACGU - 92 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
References
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