Stem-loop hsa-mir-219a-1

Accession

MI0000296

Symbol

HGNC: MIR219A1

Description

Homo sapiens hsa-mir-219a-1 precursor miRNA mir-219

Gene
family

RF00251; mir-219

Literature search

70 open access papers mention hsa-mir-219a-1
(248 sentences)

Sequence

1339 reads, 9 reads per million, 84 experiments

ccgccccgggccgcggcuccUGAUUGUCCAAACGCAAUUCUcgagucuauggcuccggccgAGAGUUGAGUCUGGACGUCCCGagccgccgcccccaaaccucgagcggg
((((.(.((((.(((((((..(((.(((((.((.(((((((((.(((.........)))))))))))).)).))))))))..))))))).)))).........).)))).

Structure

-    c --------c    c       cU   U     A  G         a   uau 
 ccgc c         gggc gcggcuc  GAU GUCCA AC CAAUUCUcg guc   g
 |||| |         |||| |||||||  ||| ||||| || ||||||||| |||   g
 ggcg g         cccg cgccgaG  CUG CAGGU UG GUUGAGAgc cgg   c
g    a cuccaaacc    c       CC   -     C  A         -   ccu 

Annotation confidence High

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the 5' excised miR has been validated in zebrafish, and the 5' end mapped by PCR [2]. The mature products were later validated in human [3]. Two hairpin precursor structures are predicted, mir-219-1 on chromosome 6 (MIR:MI0000296) and mir-219-2 on chromosome 9 (MIR:MI0000740) [2].

Genome context

chr6: 33207835-33207944 [+]

Disease association

hsa-mir-219a-1 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-219a-5p

• Accession: MIMAT0000276
• Description: Homo sapiens hsa-miR-219a-5p mature miRNA
• Sequence: 21 - UGAUUGUCCAAACGCAAUUCU - 41
• Evidence: experimental ; cloned [3]

Mature hsa-miR-219a-1-3p

• Accession: MIMAT0004567
• Description: Homo sapiens hsa-miR-219a-1-3p mature miRNA
• Sequence: 62 - AGAGUUGAGUCUGGACGUCCCG - 83
• Evidence: experimental ; cloned [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


3. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73