miRBase entry: dme-mir-276a

Stem-loop dme-mir-276a


Accession
MI0000359
Description
Drosophila melanogaster dme-mir-276a precursor miRNA
Gene family
MIPF0000124; mir-276

Literature search
15 open access papers mention dme-mir-276a
(44 sentences)

Sequence

5108720 reads, 51649 reads per million, 49 experiments
ccugguuuuugccauCAGCGAGGUAUAGAGUUCCUACGuucauuauaaacucgUAGGAACUUCAUACCGUGCUCUuggaagaccaaaaaacaaccaag
..(((((((..(((..((((.(((((.(((((((((((.............))))))))))).))))).))))..)))))))))).............

Structure
-----------cc       ug   uC    A     A           uucau 
             ugguuuu  cca  AGCG GGUAU GAGUUCCUACG     u
             |||||||  |||  |||| ||||| |||||||||||     a
             accagaa  ggu  UCGU CCAUA UUCAAGGAUgc     u
gaaccaacaaaaa       --   UC    G     C           ucaaa 


Annotation confidence High
Do you think this miRNA is real?
Comments
miR-276 was reported independently in references [1] and [2]. Reference [2] reported a 22 nt excised sequence from the 3' arm of the precursor by cloning. Computational approaches followed by Northern blotting predicted an excised sequence from the 5' arm which is designated miR-276a* here [1].

Genome context
chr3L: 10365228-10365325 [+]

Database links

Mature dme-miR-276a-5p

Accession MIMAT0000336
Description Drosophila melanogaster dme-miR-276a-5p mature miRNA
Sequence 16 - CAGCGAGGUAUAGAGUUCCUACG - 38
Evidence experimental
Northern [1], 454 [3-4], Illumina [4]
Database links

Mature dme-miR-276a-3p

Accession MIMAT0000337
Description Drosophila melanogaster dme-miR-276a-3p mature miRNA
Sequence 54 - UAGGAACUUCAUACCGUGCUCU - 75
Evidence experimental
Northern [1], cloned [2], 454 [3-4], Illumina [4]
Database links
Predicted targets

References

  1. PubMed ID: 12919683
    The small RNA profile during Drosophila melanogaster development
    "Aravin AA, Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T"
    "Dev Cell (2003) 5:337-350

  2. PubMed ID: 17989254
    Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs
    "Ruby JG, Stark A, Johnston WK, Kellis M, Bartel DP, Lai EC"
    "Genome Res (2007) 17:1850-1864

  3. PubMed ID: 17989255
    Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
    "Stark A, Kheradpour P, Parts L, Brennecke J, Hodges E, Hannon GJ, Kellis M"
    "Genome Res (2007) 17:1865-1879

  4. PubMed ID: 12844358
    Computational identification of Drosophila microRNA genes
    "Lai EC, Tomancak P, Williams RW, Rubin GM"
    "Genome Biol (2003) 4:R42