Stem-loop sequence hsa-mir-122

Accession

MI0000442 (change log)

Previous IDs

hsa-mir-122a

Symbol

HGNC:MIR122

Description

Homo sapiens miR-122 stem-loop

Gene family

MIPF0000095; mir-122

Literature search

562 open access papers mention hsa-mir-122
(3957 sentences)

Stem-loop

   c        -      gg       c           --u  c 
5'  cuuagcag agcugu  aguguga aaugguguuug   gu u
    |||||||| ||||||  ||||||| |||||||||||   ||  
3'  ggaucguc ucgaua  ucacacu uuaccgcaaac   ca a
   c        a      aa       a           uau  a 

Deep sequencing

378121 reads, 1.2e+03 reads per million, 101 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr18: 58451074-58451158 [+]
• Overlapping transcripts:

  antisense

  OTTHUMT00000449086 ; RP11-325K19.1-001; intron 3

  ENST00000591869 ; RP11-325K19.1-001; intron 3

Clustered miRNAs

< 10kb from hsa-mir-122

• hsa-mir-122: chr18: 58451074-58451158 [+]
• hsa-mir-122b: chr18: 58451080-58451152 [-]

Database links

• EntrezGene:MIR122
• HGNC:MIR122
• RNAcentral:URS000075E935_9606
• miRBase Tracker:MI0000442

Mature sequence hsa-miR-122-5p

• Accession: MIMAT0000421
• Previous IDs: hsa-miR-122a;hsa-miR-122
• Sequence: 15 - uggagugugacaaugguguuug - 36
• Deep sequencing: 359326 reads, 100 experiments
• Evidence: experimental; cloned [2-3], Northern [2]
• Database links:
  • RNAcentral:URS00003380CC_9606
• Predicted targets:
  • TargetMiner:hsa-miR-122-5p
  • TargetScanVert:hsa-miR-122-5p
  • miRDB:hsa-miR-122-5p
  • microrna.org:hsa-miR-122-5p

Mature sequence hsa-miR-122-3p

• Accession: MIMAT0004590
• Previous IDs: hsa-miR-122*
• Sequence: 51 - aacgccauuaucacacuaaaua - 72
• Deep sequencing: 18779 reads, 15 experiments
• Evidence: experimental; cloned [3]
• Predicted targets:
  • TargetMiner:hsa-miR-122-3p
  • TargetScanVert:hsa-miR-122-3p
  • miRDB:hsa-miR-122-3p
  • microrna.org:hsa-miR-122-3p

References

1. PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2. PMID:15978578 "Identification of human fetal liver miRNAs by a novel method" Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X FEBS Lett. 579:3849-3854(2005).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).