MIR133A1 is a gene encoding the miR-133a1 microRNA, located on chromosome 18q11.2, and is one of the two genes responsible for the production of mature miR-133a in humans [PMC6522747]. This microRNA is predominantly expressed in muscle tissues and is implicated in muscle differentiation and myogenesis [PMC5137429]. It has been identified as a downregulated gene in glioma samples when compared to normal samples, suggesting its potential role as an oncosuppressor RNA gene (OSRG) [PMC8634738]. During cardiomyogenesis from pluripotent stem cells, MIR133A1 expression increases by day 10, indicating its importance in cardiac lineage differentiation [PMC6828809]. Furthermore, MIR133A1 has been shown to promote pre-cardiac mesoderm development while inhibiting endodermal and neuroectodermal lineages [PMC6828809]. In the context of prostate tumors, MIR133A1 downregulation due to overexpression of transcription factor ESF1 leads to upregulation of EGFR, which is associated with cell proliferation and metastasis [PMC8840188]. Genetic screening studies have included MIR133A1 to investigate its role in familial atrial fibrillation (AF), highlighting its significance in cardiac-related conditions [PMC3599331].
a uuu g AA U A gccuc caaugc gcua AGCUGGU AA GG ACCAAAUc u |||||| |||| ||||||| || || |||||||| guuacg cgau UCGACCA UU CC UGGUUUag u a uau G AC C C guaac
Name | Accession | Chromosome | Start | End | Strand | Confidence |
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Disease | Description | Category | PubMed ID |
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Accession | MIMAT0000427 |
Description | Homo sapiens hsa-miR-133a-3p mature miRNA |
Sequence | 53 - UUUGGUCCCCUUCAACCAGCUG - 74 |
Evidence |
experimental
cloned [2], Illumina [3] |
Database links |
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Predicted targets |
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Accession | MIMAT0026478 |
Description | Homo sapiens hsa-miR-133a-5p mature miRNA |
Sequence | 16 - AGCUGGUAAAAUGGAACCAAAU - 37 |
Evidence |
experimental
Illumina [3] |
Database links |
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Predicted targets |
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