Stem-loop hsa-mir-141

Accession

MI0000457

Symbol

HGNC: MIR141

Description

Homo sapiens hsa-mir-141 precursor miRNA mir-8

Gene
family

RF00241; mir-8

Literature search

359 open access papers mention hsa-mir-141
(1909 sentences)

Sequence

93084 reads, 294 reads per million, 140 experiments

cggccggcccugggucCAUCUUCCAGUACAGUGUUGGAuggucuaauugugaagcuccUAACACUGUCUGGUAAAGAUGGcucccggguggguuc
.((((.((((.(((.(((((((((((.(((((((((((...((.......))...))).))))))))))))..)))))))..))))))).)))).

Structure

c    g    u   -u       --    U        -   ugg  ua 
 ggcc gccc ggg  cCAUCUU  CCAG ACAGUGUU GGA   uc  a
 |||| |||| |||  |||||||  |||| |||||||| |||   ||  u
 uugg uggg ccc  GGUAGAA  GGUC UGUCACAA ccu   ag  u
c    g    -   uc       AU    -        U   cga  ug 

Annotation confidence High

Comments

This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-141 in human [2].

Genome context

chr12: 6964097-6964191 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-141

Disease association

hsa-mir-141 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-141-5p

• Accession: MIMAT0004598
• Description: Homo sapiens hsa-miR-141-5p mature miRNA
• Sequence: 17 - CAUCUUCCAGUACAGUGUUGGA - 38
• Evidence: experimental ; cloned [3]

Mature hsa-miR-141-3p

• Accession: MIMAT0000432
• Description: Homo sapiens hsa-miR-141-3p mature miRNA
• Sequence: 59 - UAACACUGUCUGGUAAAGAUGG - 80
• Evidence: experimental ; cloned [2-4]

References

1. PubMed ID: 14573789
   Reduced accumulation of specific microRNAs in colorectal neoplasia
   "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
   "Mol Cancer Res (2003) 1:882-891


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


4. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739