miRBase entry: hsa-mir-127

Stem-loop hsa-mir-127


Accession
MI0000472
Symbol
HGNC: MIR127
Description
Homo sapiens hsa-mir-127 precursor miRNA mir-127
Gene
family?
RF00676; mir-127

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR127 is a microRNA encoded by RTL1as and functions as a repressor for RTL1 expression through the RNAi mechanism, as observed in the interaction between mouse Rtl1 and Rtl1as [PMC3469456]. This microRNA, particularly miR-127-3p, is implicated in the regulation of inflammatory responses, targeting IgG FcγRI (CD64) and modulating cytokine release by macrophages during lung inflammation [PMC5247697].

Literature search
154 open access papers mention hsa-mir-127
(925 sentences)

Sequence

110941 reads, 596 reads per million, 103 experiments
ugugaucacugucuccagccugCUGAAGCUCAGAGGGCUCUGAUucagaaagaucaUCGGAUCCGUCUGAGCUUGGCUggucggaagucucaucauc
.(((((.(((...(((.(((.(((.(((((((((.((.((((((((.....))..)))))).)).)))))))))))).))).))))))...))))).

Structure
u     --c   guc   a   u   G         G  C      --  a 
 gugau   acu   ucc gcc gCU AAGCUCAGA GG UCUGAU  uc g
 |||||   |||   ||| ||| ||| ||||||||| || ||||||  || a
 uacua   uga   agg ugg CGG UUCGAGUCU CC AGGCUa  ag a
c     cuc   ---   c   U   -         G  U      cu  a 


Annotation confidence High
Do you think this miRNA is real?
Comments
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. The expression of this miRNA was later confirmed by cloning in human cells [2,3].

Genome context
chr14: 100882979-100883075 [+]
Clustered miRNAs
6 other miRNAs are < 10 kb from hsa-mir-127
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-127 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-127-5p

Accession MIMAT0004604
Description Homo sapiens hsa-miR-127-5p mature miRNA
Sequence 23 - CUGAAGCUCAGAGGGCUCUGAU - 44
Evidence experimental
cloned [3-4]
Database links
Predicted targets

Mature hsa-miR-127-3p

Accession MIMAT0000446
Description Homo sapiens hsa-miR-127-3p mature miRNA
Sequence 57 - UCGGAUCCGUCUGAGCUUGGCU - 78
Evidence experimental
cloned [2-3]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 18230126
    New miRNAs cloned from neuroblastoma
    "Afanasyeva EA, Hotz-Wagenblatt A, Glatting KH, Westermann F"
    "BMC Genomics (2008) 9:52

  3. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  4. PubMed ID: 15891114
    Clustering and conservation patterns of human microRNAs
    "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
    "Nucleic Acids Res (2005) 33:2697-2706