Stem-loop sequence hsa-mir-136

Accession

MI0000475 (change log)

Symbol

HGNC:MIR136

Description

Homo sapiens miR-136 stem-loop

Gene family

MIPF0000099; mir-136

Literature search

73 open access papers mention hsa-mir-136
(353 sentences)

Stem-loop

   u        g        c     uuu          uuc 
5'  gagcccuc gaggacuc auuug   ugaugaugga   u
    |||||||| |||||||| |||||   ||||||||||   u
3'  cuugggag cuucugag uaaac   gcuacuaccu   a
   u        a        -     ucu          cgu 

Deep sequencing

25936 reads, 77.3 reads per million, 128 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

miR-136 was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr14: 100884702-100884783 [+]
• Overlapping transcripts:

  sense

  OTTHUMT00000414309 ; WDR25-007; intron 1

  OTTHUMT00000414313 ; WDR25-008; intron 1

  OTTHUMT00000414315 ; WDR25-005; intron 1

  OTTHUMT00000414316 ; WDR25-006; intron 1

  OTTHUMT00000414310 ; WDR25-002; intron 2

  OTTHUMT00000414311 ; WDR25-001; intron 2

  OTTHUMT00000414312 ; WDR25-004; intron 2

  OTTHUMT00000414314 ; WDR25-003; intron 2

  ENST00000555775 ; WDR25-007; intron 1

  ENST00000554492 ; WDR25-008; intron 1

  ENST00000557710 ; WDR25-005; intron 1

  ENST00000542471 ; WDR25-006; intron 1

  ENST00000554998 ; WDR25-002; intron 2

  ENST00000402312 ; WDR25-001; intron 2

  ENST00000335290 ; WDR25-004; intron 2

  ENST00000554175 ; WDR25-003; intron 2

Clustered miRNAs

< 10kb from hsa-mir-136

• hsa-mir-665: chr14: 100875033-100875104 [+]
• hsa-mir-431: chr14: 100881007-100881120 [+]
• hsa-mir-433: chr14: 100881886-100881978 [+]
• hsa-mir-127: chr14: 100882979-100883075 [+]
• hsa-mir-432: chr14: 100884483-100884576 [+]
• hsa-mir-136: chr14: 100884702-100884783 [+]

Database links

• EntrezGene:MIR136
• HGNC:MIR136
• RNAcentral:URS00002130B2_9606
• miRBase Tracker:MI0000475

Mature sequence hsa-miR-136-5p

• Accession: MIMAT0000448
• Previous IDs: hsa-miR-136
• Sequence: 15 - acuccauuuguuuugaugaugga - 37
• Deep sequencing: 10676 reads, 128 experiments
• Evidence: experimental; cloned [2-4]
• Database links:
  • RNAcentral:URS00004EAB18_9606
• Predicted targets:
  • TargetMiner:hsa-miR-136-5p
  • TargetScanVert:hsa-miR-136-5p
  • miRDB:hsa-miR-136-5p
  • microrna.org:hsa-miR-136-5p

Mature sequence hsa-miR-136-3p

• Accession: MIMAT0004606
• Previous IDs: hsa-miR-136*
• Sequence: 49 - caucaucgucucaaaugagucu - 70
• Deep sequencing: 15249 reads, 118 experiments
• Evidence: experimental; cloned [4]
• Database links:
  • RNAcentral:URS0000204177_9606
• Predicted targets:
  • TargetMiner:hsa-miR-136-3p
  • TargetScanVert:hsa-miR-136-3p
  • miRDB:hsa-miR-136-3p
  • microrna.org:hsa-miR-136-3p

References

1. PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2. PMID:15183728 "Human embryonic stem cells express a unique set of microRNAs" Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS Dev Biol. 270:488-498(2004).
3. PMID:15891114 "Clustering and conservation patterns of human microRNAs" Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H Nucleic Acids Res. 33:2697-2706(2005).
4. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).