Stem-loop hsa-mir-136

Accession

MI0000475

Symbol

HGNC: MIR136

Description

Homo sapiens hsa-mir-136 precursor miRNA mir-136

Gene
family

RF00687; mir-136

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR136 is a microRNA observed to increase in expression levels during the transition of preadipocytes to mature adipocytes, particularly between the 8th and 10th day of adipocyte development [PMC9928478]. Concurrently, the expression of PPARGC1B, a gene implicated in this differentiation process, decreases [PMC9928478]. The study conducted an analysis to understand MIR136's role in preadipocyte proliferation and differentiation, as well as its regulatory interactions with PPARGC1B and other key adipogenic factors such as PPARγ, C/EBPα, and IGF1 [PMC9928478].

Literature search

73 open access papers mention hsa-mir-136
(354 sentences)

Sequence

14705 reads, 338 reads per million, 101 experiments

ugagcccucggaggACUCCAUUUGUUUUGAUGAUGGAuucuuaugcucCAUCAUCGUCUCAAAUGAGUCUucagaggguucu
.((((((((.((((((((.(((((...((((((((((.........))))))))))...))))))))))))).)))))))).

Structure

u        g        C     UUU          uuc 
 gagcccuc gaggACUC AUUUG   UGAUGAUGGA   u
 |||||||| |||||||| |||||   ||||||||||   u
 cuugggag cuUCUGAG UAAAC   GCUACUACcu   a
u        a        -     UCU          cgu 

Annotation confidence High

Comments

miR-136 was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2].

Genome context

chr14: 100884702-100884783 [+]

Clustered miRNAs

5 other miRNAs are < 10 kb from hsa-mir-136

Disease association

hsa-mir-136 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-136-5p

• Accession: MIMAT0000448
• Description: Homo sapiens hsa-miR-136-5p mature miRNA
• Sequence: 15 - ACUCCAUUUGUUUUGAUGAUGGA - 37
• Evidence: experimental ; cloned [2-4]

Mature hsa-miR-136-3p

• Accession: MIMAT0004606
• Description: Homo sapiens hsa-miR-136-3p mature miRNA
• Sequence: 49 - CAUCAUCGUCUCAAAUGAGUCU - 70
• Evidence: experimental ; cloned [4]

References

1. PubMed ID: 15183728
   Human embryonic stem cells express a unique set of microRNAs
   "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
   "Dev Biol (2004) 270:488-498


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


4. PubMed ID: 15891114
   Clustering and conservation patterns of human microRNAs
   "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
   "Nucleic Acids Res (2005) 33:2697-2706