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miRBase |
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Stem-loop sequence mmu-mir-196a-1 |
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Accession | MI0000552 (change log) | ||||
Previous IDs | mmu-mir-196-1 | ||||
Symbol | MGI:Mir196a-1 | ||||
Description | Mus musculus miR-196a-1 stem-loop | ||||
Gene family | MIPF0000031; mir-196 | ||||
Literature search |
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67 open access papers mention mmu-mir-196a-1 | ||||
Stem-loop |
u c gg uga g a c - gc ugg 5' gagc g acugu gugaa uaggu guuu auguuguug g c c |||| | ||||| ||||| ||||| |||| ||||||||| | | u 3' uucg c ugacg uacuu gucca caaa uacagcaac c g u c u au --g a c c a aa ucu |
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Deep sequencing |
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Confidence |
Annotation confidence: high
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Comments |
Yekta et al. report that miR-196 miRNAs are expressed from HOX gene clusters in mammals, and that HOX genes in these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown to be a natural target for miR-196-directed cleavage through a perfectly complementary miR-target site. Other HOX genes have imperfect miR-196 complementary sites indicative of regulation by translational repression [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3]. |
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Genome context |
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Database links |
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Mature sequence mmu-miR-196a-5p |
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Accession | MIMAT0000518 |
Previous IDs | mmu-miR-196a |
Sequence |
24 - uagguaguuucauguuguuggg - 45 |
Deep sequencing | 1133875 reads, 90 experiments |
Evidence | experimental; cloned [1,3], Illumina [4-5] |
Database links |
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Predicted targets |
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Mature sequence mmu-miR-196a-1-3p |
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Accession | MIMAT0017013 |
Previous IDs | mmu-miR-196a-1* |
Sequence |
62 - caacgacaucaaaccaccugau - 83 |
Deep sequencing | 2859 reads, 39 experiments |
Evidence | experimental; 454 [5], Illumina [6] |
Database links |
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Predicted targets |
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References |
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1 |
PMID:12554859
"New microRNAs from mouse and human"
RNA. 9:175-179(2003).
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2 |
PMID:15105502
"MicroRNA-directed cleavage of HOXB8 mRNA"
Science. 304:594-596(2004).
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3 |
PMID:17604727
"A mammalian microRNA expression atlas based on small RNA library sequencing"
Cell. 129:1401-1414(2007).
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4 |
PMID:20215419
"MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing"
Mol Hum Reprod. 16:463-471(2010).
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5 |
PMID:20668074
"Identification and analysis of expression of novel microRNAs of murine gammaherpesvirus 68"
J Virol. 84:10266-10275(2010).
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6 |
PMID:20413612
"Mammalian microRNAs: experimental evaluation of novel and previously annotated genes"
Genes Dev. 24:992-1009(2010).
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