Stem-loop sequence mmu-mir-34a

Accession

MI0000584 (change log)

Previous IDs

mmu-mir-172;mmu-mir-34c

Symbol

MGI:Mir34a

Description

Mus musculus miR-34a stem-loop

Gene family

MIPF0000039; mir-34

Literature search

388 open access papers mention mmu-mir-34a
(5429 sentences)

Stem-loop

   c   c    -    a    uu        -   a          --gug   a 
5'  cag ugug agua uucu  ggcagugu cuu gcugguuguu     agu u
    ||| |||| |||| ||||  |||||||| ||| ||||||||||     |||  
3'  guu acac ucgu aaga  ccgucaua gaa cgacuaacga     ucg u
   u   -    g    g    uc        u   -          aggaa   a 

Deep sequencing

57713 reads, 307 reads per million, 106 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

Houbaviy et al. cloned this miRNA from embryonic stem cells and named it miR-172 [1]. This sequence is homologous to human miR-34a (MI0000268), and so is renamed miR-34a here. This sequence is not related to miR172 from plants (MI0000215 and MI0000216). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chr4: 150068454-150068555 [+]
• Overlapping transcripts:

  intergenic

Database links

• EntrezGene:Mirn34a
• MGI:Mir34a
• RNAcentral:URS000075E272_10090
• miRBase Tracker:MI0000584

Mature sequence mmu-miR-34a-5p

• Accession: MIMAT0000542
• Previous IDs: mmu-miR-34a
• Sequence: 20 - uggcagugucuuagcugguugu - 41
• Deep sequencing: 55682 reads, 104 experiments
• Evidence: experimental; cloned [1,3], Illumina [4,6]
• Database links:
  • RNAcentral:URS000030BD69_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-34a-5p
  • miRDB:mmu-miR-34a-5p
  • microrna.org:mmu-miR-34a-5p

Mature sequence mmu-miR-34a-3p

• Accession: MIMAT0017022
• Previous IDs: mmu-miR-34a*
• Sequence: 64 - aaucagcaaguauacugcccu - 84
• Deep sequencing: 1895 reads, 82 experiments
• Evidence: experimental; 454 [5], Illumina [6]
• Database links:
  • RNAcentral:URS00005E520A_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-34a-3p
  • miRDB:mmu-miR-34a-3p

References

1. PMID:12919684 "Embryonic stem cell-specific MicroRNAs" Houbaviy HB, Murray MF, Sharp PA Dev Cell. 5:351-358(2003).
2. PMID:12554860 "Numerous microRNPs in neuronal cells containing novel microRNAs" Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G RNA. 9:180-186(2003).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
4. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
5. PMID:20668074 "Identification and analysis of expression of novel microRNAs of murine gammaherpesvirus 68" Zhu JY, Strehle M, Frohn A, Kremmer E, Hofig KP, Meister G, Adler H J Virol. 84:10266-10275(2010).
6. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).