Stem-loop rno-mir-323

Accession

MI0000591

Description

Rattus norvegicus rno-mir-323 precursor miRNA

Gene family

MIPF0000018; mir-154

Literature search

7 open access papers mention rno-mir-323
(19 sentences)

Sequence

60442 reads, 1700 reads per million, 357 experiments

uugguacuuggagagAGGUGGUCCGUGGCGCGUUCGCuucauuuauggcgCACAUUACACGGUCGACCUCUuugcgguaucuaauc
..((((((.(.((((((((.(.(((((..(.((.((((........)))).)).)..))))).).)))))))).))))))).....

Structure

---uu      u g        G U     GC C  U    uca 
     gguacu g agagAGGU G CCGUG  G GU CGCu   u
     |||||| | |||||||| | |||||  | || ||||    
     cuaugg c uuUCUCCA C GGCAC  U CA gcgg   u
cuaau      - g        G U     AU A  C    uau 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context

chr6: 133861199-133861284 [+]

Clustered miRNAs

15 other miRNAs are < 10 kb from rno-mir-323

Mature rno-miR-323-5p

• Accession: MIMAT0004637
• Description: Rattus norvegicus rno-miR-323-5p mature miRNA
• Sequence: 16 - AGGUGGUCCGUGGCGCGUUCGC - 37
• Evidence: experimental ; cloned [3], SOLiD [4]

Mature rno-miR-323-3p

• Accession: MIMAT0000550
• Description: Rattus norvegicus rno-miR-323-3p mature miRNA
• Sequence: 51 - CACAUUACACGGUCGACCUCU - 71
• Evidence: experimental ; cloned [1-3], Northern [1], SOLiD [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365


3. PubMed ID: 20403161
   Small RNA expression and strain specificity in the rat
   Linsen SE, de Wit E, de Bruijn E, Cuppen E
   BMC Genomics (2010) 11:249


4. PubMed ID: 15345052
   Microarray analysis of microRNA expression in the developing mammalian brain
   Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
   Genome Biol (2004) 5:R68