Stem-loop mmu-mir-346

Accession

MI0000634

Symbol

MGI: Mir346

Description

Mus musculus mmu-mir-346 precursor miRNA

Gene family

MIPF0000188; mir-346

Literature search

25 open access papers mention mmu-mir-346
(301 sentences)

Sequence

712 reads, 58 reads per million, 32 experiments

ucuguguugggcgucUGUCUGCCCGAGUGCCUGCCUCUcuguugcucugaaggAGGCAGGGGCUGGGCCUGCAGCugccugggcagagcugcuccuuc
(((((..((((((.((((..((((.(((.((((((((.((..........)))))))))).)))))))..)))).)))))).)))))...........

Structure

-----------     gu      u    CU    G   G        U  guug 
           ucugu  ugggcg cUGU  GCCC AGU CCUGCCUC cu    c
           |||||  |||||| ||||  |||| ||| |||||||| ||     
           agacg  guccgu GACG  CGGG UCG GGACGGAg ga    u
cuuccucgucg     -g      C    UC    -   G        -  aguc 

Annotation confidence Not enough data

Comments

Kim et al. cloned 40 new miRNAs from rat E18 primary cortical neurons [1]. This mouse miRNA is predicted based on homology to the verified rat sequence (MIR:MI0000633) - its expression has not been verified in mouse. The sequence reported in [1] contains two 3' terminal A residues, which conflict with the precursor sequence shown here.

Genome context

chr14: 34894609-34894706 [+]

Mature mmu-miR-346-5p

• Accession: MIMAT0000597
• Description: Mus musculus mmu-miR-346-5p mature miRNA
• Sequence: 16 - UGUCUGCCCGAGUGCCUGCCUCU - 38
• Evidence: experimental ; Illumina [2-3]

Mature mmu-miR-346-3p

• Accession: MIMAT0017039
• Description: Mus musculus mmu-miR-346-3p mature miRNA
• Sequence: 54 - AGGCAGGGGCUGGGCCUGCAGC - 75
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


2. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


3. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365