Stem-loop sequence mmu-mir-222

Accession

MI0000710

Symbol

MGI:Mir222

Description

Mus musculus miR-222 stem-loop

Gene family

MIPF0000051; mir-221

Stem-loop

-  c    u              -     auc   ucuu 
 cc ucag ggcucaguagccag uguag   cug    u
 || |||| |||||||||||||| |||||   |||    g
 gg gguc cugggucaucgguc acauc   gac    g
c  u    u              u     gac   uaau 

Deep sequencing

1345471 reads, 97 experiments

Comments

Mouse mir-222 is predicted [2] based on homology to a reported miR from human (MI0000299 ) [1]. Its expression was later verified in mouse by cloning [3].

Genome context

• Coordinates (GRCm38): chrX: 19146893-19146971 [-]
• Overlapping transcripts:

  intergenic

Clustered miRNAs

< 10kb from mmu-mir-222

• mmu-mir-222: chrX: 19146893-19146971 [-]
• mmu-mir-221: chrX: 19146294-19146388 [-]

Database links

• ENTREZGENE: 723828;Mir222
• MGI: 3619118;Mir222

Mature sequence mmu-miR-222-5p

• Accession: MIMAT0017061
• Previous IDs: mmu-miR-222*
• Sequence: 12 - ucaguagccaguguagauccu - 32
• Deep sequencing: 1073 reads, 62 experiments
• Evidence: experimental; 454 [5], Solexa [6]
• Predicted targets:
  • DIANA-MICROT:mmu-miR-222-5p
  • MIRDB:mmu-miR-222-5p
  • RNA22-MMU:mmu-miR-222-5p

Mature sequence mmu-miR-222-3p

• Accession: MIMAT0000670
• Previous IDs: mmu-miR-222
• Sequence: 49 - agcuacaucuggcuacugggu - 69
• Deep sequencing: 438476 reads, 82 experiments
• Evidence: experimental; cloned [3], Solexa [4,6]
• Validated targets:
  • TARBASE:mmu-miR-222-3p
• Predicted targets:
  • DIANA-MICROT:mmu-miR-222-3p
  • MICRORNA.ORG:mmu-miR-222-3p
  • MIRDB:mmu-miR-222-3p
  • RNA22-MMU:mmu-miR-222-3p
  • TARGETSCAN-VERT:mmu-miR-222

References

1. PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
2. PMID:15634332 "New human and mouse microRNA genes found by homology search" Weber MJ FEBS J. 272:59-73(2005).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
4. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
5. PMID:20668074 "Identification and analysis of expression of novel microRNAs of murine gammaherpesvirus 68" Zhu JY, Strehle M, Frohn A, Kremmer E, Hofig KP, Meister G, Adler H J Virol. 84:10266-10275(2010).
6. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).