Stem-loop mmu-mir-199a-2

Accession

MI0000713

Symbol

MGI: Mir199a-2

Description

Mus musculus mmu-mir-199a-2 precursor miRNA mir-199

Gene
family

RF00144; mir-199

Literature search

164 open access papers mention mmu-mir-199a-2
(1326 sentences)

Sequence

3291352 reads, 15561 reads per million, 106 experiments

uggaagcuucaggagauccugcuccgucgcCCCAGUGUUCAGACUACCUGUUCaggacaaugccguuguACAGUAGUCUGCACAUUGGUUAgacugggcaagggccagca
.....(((...((...((((((((.(((...(((((((.((((((((.(((.((((......))..)).))))))))))).)))))))...))).)))).))))))))).

Structure

uggaa   uca  aga    -    c   gcC       U        C   U  --  ac 
     gcu   gg   uccu gcuc guc   CCAGUGU CAGACUAC UGU Ca  gg  a
     |||   ||   |||| |||| |||   ||||||| |||||||| ||| ||  ||   
     cga   cc   ggga cggg cag   GGUUACA GUCUGAUG ACA gu  cc  a
----a   ---  ---    a    u   AUU       C        -   u  ug  gu 

Annotation confidence Medium

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

chr1: 162217814-162217923 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from mmu-mir-199a-2

Mature mmu-miR-199a-5p

• Accession: MIMAT0000229
• Description: Mus musculus mmu-miR-199a-5p mature miRNA
• Sequence: 31 - CCCAGUGUUCAGACUACCUGUUC - 53
• Evidence: experimental ; cloned [5], Illumina [6-7]

Mature mmu-miR-199a-3p

• Accession: MIMAT0000230
• Description: Mus musculus mmu-miR-199a-3p mature miRNA
• Sequence: 70 - ACAGUAGUCUGCACAUUGGUUA - 91
• Evidence: experimental ; cloned [1,5], Illumina [6-7]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


3. PubMed ID: 12554859
   New microRNAs from mouse and human
   "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
   "RNA (2003) 9:175-179


4. PubMed ID: 12919684
   Embryonic stem cell-specific MicroRNAs
   "Houbaviy HB, Murray MF, Sharp PA"
   "Dev Cell (2003) 5:351-358


5. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


6. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


7. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73