Accession
MI0000769
Symbol
HGNC:
MIR365B
Description
Homo sapiens
hsa-mir-365b precursor miRNA mir-365
Gene
family?
family?
RF00659;
mir-365
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR365B is a microRNA gene located within the 1.4-Mb NF1 microdeletion region, which is associated with neurofibromatosis type 1 (NF1) [PMC5370280]. This gene, along with MIR193A, is hemizygous in patients with NF1 microdeletions and may contribute to the tumorigenesis observed in these patients [PMC5370280]. Although the role of MIR365B in malignant peripheral nerve sheath tumor (MPNST) pathogenesis is not as well understood as that of SUZ12, it is considered to have putative tumor suppressor functions [PMC5370280]. Research has identified that MIR365B, along with other miRNAs like miR-4262 and miR-506-3p, can target GALNT4 to suppress tumor growth [PMC8504460]. Additionally, POINT-5 analysis has detected significant peaks indicative of Drosha cleavage activity over MIR365B derived from a long noncoding RNA (lncRNA), suggesting its involvement in RNA processing events related to tumorigenesis [PMC8122139]. The presence of MIR365B within the NF1 microdeletion region alongside other genes like ATAD5 and miR193A underscores its potential significance as a tumor suppressor gene within this genomic context [PMC8395254].
Literature search
61 open access papers mention hsa-mir-365b
(319 sentences)
(319 sentences)
Sequence
83123
reads,
1088
reads per million, 133 experiments
agaguguucaaggacagcaagaaaaaugAGGGACUUUCAGGGGCAGCUGUguuuucugacucagucaUAAUGCCCCUAAAAAUCCUUAUuguucuugcagugugcaucggg
...........(.((((((((((.((((((((..(((.(((((((((((.(((....))).)))).....))))))).))).)))))))).)))))))..))).)......
...........(.((((((((((.((((((((..(((.(((((((((((.(((....))).)))).....))))))).))).)))))))).)))))))..))).)......
Structure
agaguguucaa g -- a AC C ----- U u
g aca gcaagaa aaugAGGG UUU AGGGGCA GCUG guu u
| ||| ||||||| |||||||| ||| ||||||| |||| |||
c ugu cguucuu uUAUUCCU AAA UCCCCGU ugac cag c
-----gggcua g ga g -A A AAUac u u
Annotation confidence
High
Do you think this miRNA is real?
Comments
Xie et al. [1] refer to this sequence by the internal identifier MIR190. The sequence is unrelated to mammalian mir-190 (MIR:MI0000486).
Genome context
chr17: 31575411-31575521 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-365b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-365b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-365b-5p
| Accession | MIMAT0022833 |
| Description | Homo sapiens hsa-miR-365b-5p mature miRNA |
| Sequence | 29 - AGGGACUUUCAGGGGCAGCUGU - 50 |
| Evidence |
experimental
454 [5] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-365b-3p
| Accession | MIMAT0022834 |
| Description | Homo sapiens hsa-miR-365b-3p mature miRNA |
| Sequence | 68 - UAAUGCCCCUAAAAAUCCUUAU - 89 |
| Evidence |
experimental
cloned [1,3-4], array-cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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