Stem-loop sequence hsa-mir-379

Accession

MI0000787 (change log)

Symbol

HGNC:MIR379

Description

Homo sapiens miR-379 stem-loop

Gene family

MIPF0000126; mir-379

Literature search

48 open access papers mention hsa-mir-379
(227 sentences)

Stem-loop

       a    a       ga       -  uu u 
5' agag uggu gacuaug  acguagg cg  a g
   |||| |||| |||||||  ||||||| ||  |  
3' ucuc auca cugguac  uguaucc gu  u a
       a    c       aa       a  cu u 

Deep sequencing

175873 reads, 264 reads per million, 130 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr14: 101022066-101022132 [+]
• Overlapping transcripts:

  antisense

  OTTHUMT00000414334 ; BEGAIN-007; intron 1

  OTTHUMT00000414329 ; BEGAIN-001; intron 2

  OTTHUMT00000414331 ; BEGAIN-005; intron 2

  OTTHUMT00000414332 ; BEGAIN-003; intron 2

  OTTHUMT00000414335 ; BEGAIN-006; intron 2

  OTTHUMT00000414337 ; BEGAIN-004; intron 2

  ENST00000557378 ; BEGAIN-007; intron 1

  ENST00000443071 ; BEGAIN-201; intron 1

  ENST00000355173 ; BEGAIN-001; intron 2

  ENST00000553553 ; BEGAIN-005; intron 2

  ENST00000556188 ; BEGAIN-003; intron 2

  ENST00000554140 ; BEGAIN-006; intron 2

  ENST00000554747 ; BEGAIN-004; intron 2

Clustered miRNAs

< 10kb from hsa-mir-379

• hsa-mir-379: chr14: 101022066-101022132 [+]
• hsa-mir-411: chr14: 101023325-101023420 [+]
• hsa-mir-299: chr14: 101023794-101023856 [+]
• hsa-mir-380: chr14: 101025017-101025077 [+]
• hsa-mir-1197: chr14: 101025564-101025651 [+]
• hsa-mir-323a: chr14: 101025732-101025817 [+]
• hsa-mir-758: chr14: 101026020-101026107 [+]
• hsa-mir-329-1: chr14: 101026785-101026864 [+]
• hsa-mir-329-2: chr14: 101027100-101027183 [+]
• hsa-mir-494: chr14: 101029634-101029714 [+]
• hsa-mir-1193: chr14: 101030052-101030129 [+]
• hsa-mir-543: chr14: 101031987-101032064 [+]

Database links

• EntrezGene:MIR379
• HGNC:MIR379
• RNAcentral:URS000075EEE5_9606
• miRBase Tracker:MI0000787

Mature sequence hsa-miR-379-5p

• Accession: MIMAT0000733
• Previous IDs: hsa-miR-379
• Sequence: 6 - ugguagacuauggaacguagg - 26
• Deep sequencing: 171993 reads, 122 experiments
• Evidence: experimental; cloned [2-4]
• Database links:
  • RNAcentral:URS000060A1F4_9606
• Predicted targets:
  • TargetMiner:hsa-miR-379-5p
  • TargetScanVert:hsa-miR-379-5p
  • miRDB:hsa-miR-379-5p
  • microrna.org:hsa-miR-379-5p

Mature sequence hsa-miR-379-3p

• Accession: MIMAT0004690
• Previous IDs: hsa-miR-379*
• Sequence: 44 - uauguaacaugguccacuaacu - 65
• Deep sequencing: 3880 reads, 118 experiments
• Evidence: experimental; cloned [4]
• Database links:
  • RNAcentral:URS00001EE123_9606
• Predicted targets:
  • TargetMiner:hsa-miR-379-3p
  • TargetScanVert:hsa-miR-379-3p
  • miRDB:hsa-miR-379-3p
  • microrna.org:hsa-miR-379-3p

References

1. PMID:15538371 "A pancreatic islet-specific microRNA regulates insulin secretion" Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M Nature. 432:226-230(2004).
2. PMID:15891114 "Clustering and conservation patterns of human microRNAs" Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H Nucleic Acids Res. 33:2697-2706(2005).
3. PMID:16274478 "Identification of clustered microRNAs using an ab initio prediction method" Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M BMC Bioinformatics. 6:267(2005).
4. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).