Stem-loop sequence mmu-mir-377

Accession

MI0000794

Symbol

MGI:Mir377

Description

Mus musculus miR-377 stem-loop

Gene family

MIPF0000018; mir-154

Stem-loop

u              c   -    a    - uuu 
 gagcagagguugcc uug guga uucg c   a
 |||||||||||||| ||| |||| |||| |   u
 uuuguuuucaacgg aac cacu aagu g   u
g              a   a    -    u uag 

Deep sequencing

41106 reads, 56 experiments

Genome context

• Coordinates (GRCm38): chr12: 109740510-109740577 [+]
• Overlapping transcripts:

  intergenic

Clustered miRNAs

< 10kb from mmu-mir-377

• mmu-mir-382: chr12: 109733771-109733846 [+]
• mmu-mir-134: chr12: 109734139-109734209 [+]
• mmu-mir-668: chr12: 109734732-109734797 [+]
• mmu-mir-485: chr12: 109734902-109734974 [+]
• mmu-mir-453: chr12: 109735619-109735700 [+]
• mmu-mir-154: chr12: 109738433-109738498 [+]
• mmu-mir-496a: chr12: 109739119-109739197 [+]
• mmu-mir-377: chr12: 109740510-109740577 [+]
• mmu-mir-541: chr12: 109742409-109742498 [+]
• mmu-mir-409: chr12: 109743158-109743236 [+]
• mmu-mir-412: chr12: 109743289-109743368 [+]
• mmu-mir-369: chr12: 109743418-109743496 [+]
• mmu-mir-410: chr12: 109743715-109743795 [+]
• mmu-mir-3072: chr12: 109747878-109747960 [+]

Database links

• ENTREZGENE: 723857;Mir377
• MGI: 3619382;Mir377

Mature sequence mmu-miR-377-5p

• Accession: MIMAT0017079
• Previous IDs: mmu-miR-377*
• Sequence: 6 - agagguugcccuuggugaauuc - 27
• Deep sequencing: 1526 reads, 40 experiments
• Evidence: experimental; Solexa [5]
• Predicted targets:
  • DIANA-MICROT:mmu-miR-377-5p
  • MIRDB:mmu-miR-377-5p
  • RNA22-MMU:mmu-miR-377-5p

Mature sequence mmu-miR-377-3p

• Accession: MIMAT0000741
• Previous IDs: mmu-miR-377
• Sequence: 44 - aucacacaaaggcaacuuuugu - 65
• Deep sequencing: 39563 reads, 50 experiments
• Evidence: experimental; cloned [1-3], Solexa [4-5]
• Predicted targets:
  • DIANA-MICROT:mmu-miR-377-3p
  • MICRORNA.ORG:mmu-miR-377-3p
  • MIRDB:mmu-miR-377-3p
  • RNA22-MMU:mmu-miR-377-3p
  • TARGETSCAN-VERT:mmu-miR-377

References

1. PMID:15538371 "A pancreatic islet-specific microRNA regulates insulin secretion" Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M Nature. 432:226-230(2004).
2. PMID:16274478 "Identification of clustered microRNAs using an ab initio prediction method" Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M BMC Bioinformatics. 6:267(2005).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
4. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
5. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).