Accession
MI0000806
Symbol
HGNC:
MIR337
Description
Homo sapiens
hsa-mir-337 precursor miRNA mir-337
Gene
family?
family?
RF00765;
mir-337
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR337 is a microRNA (miRNA) implicated in various biological processes and diseases, including head and neck cancers, although it was not detected in a specific study on these cancers [PMC5354851]. It exhibits differential expression patterns based on sex, being down-regulated in males and up-regulated in females [PMC7663125]. This miRNA is part of the Dlk1-Dio3 imprinted domain and is transcribed from the maternal chromosome [PMC3919614]. In the context of esophageal cancer, over-expression of MIR337 has been shown to significantly increase autophagy, as indicated by the conversion of LC3-I to LC3-II [PMC5302951]. However, its expression was significantly decreased in another study focusing on miRNAs, leading to it not being further examined by quantitative RT-PCR (qRT-PCR) [PMC4748271]. Additionally, MIR337 plays a role in controlling chondrogenesis of mesenchymal stem cells (MSCs) and the progression of osteoarthritis (OA) [PMC10110697].
Literature search
53 open access papers mention hsa-mir-337
(198 sentences)
(198 sentences)
Sequence
4123
reads,
197
reads per million, 88 experiments
guagucaguaguugggggguggGAACGGCUUCAUACAGGAGUUgaugcacaguuauccagCUCCUAUAUGAUGCCUUUCUUCauccccuucaa
.............((((((((((((.(((.(((((.(((((((((((......))).)))))))).))))).))).))).)))))))))....
.............((((((((((((.(((.(((((.(((((((((((......))).)))))))).))))).))).))).)))))))))....
Structure
guagucaguaguu - C U C - ca
ggggggugg GAA GGC UCAUA AGGAGUUg aug c
||||||||| ||| ||| ||||| |||||||| |||
uccccuaCU CUU CCG AGUAU UCCUCgac uau a
---------aacu U U U A c ug
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence was predicted based on homology with a verified rat miRNA [1,2], and later confirmed in human [3].
Genome context
chr14: 100874493-100874585 [+]
Clustered miRNAs
6 other miRNAs are < 10 kb from hsa-mir-337
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-337 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-337-5p
| Accession | MIMAT0004695 |
| Description | Homo sapiens hsa-miR-337-5p mature miRNA |
| Sequence | 23 - GAACGGCUUCAUACAGGAGUU - 43 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-337-3p
| Accession | MIMAT0000754 |
| Description | Homo sapiens hsa-miR-337-3p mature miRNA |
| Sequence | 61 - CUCCUAUAUGAUGCCUUUCUUC - 82 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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