miRBase entry: rno-mir-34a

Stem-loop rno-mir-34a


Accession
MI0000877
Description
Rattus norvegicus rno-mir-34a precursor miRNA
Gene family
MIPF0000039; mir-34

Literature search
130 open access papers mention rno-mir-34a
(1805 sentences)

Sequence

133513 reads, 189 reads per million, 486 experiments
ccggcugugaguaauucuuUGGCAGUGUCUUAGCUGGUUGUugugaguauuagcuaaggaagcAAUCAGCAAGUAUACUGCCCUAgaagugcugcacguugu
.((((.(((((((.((((..(((((((((((.((((((((((...(((....))).....))))))))))))).))))))))..)))).)))).))))))).

Structure
c    u   -    a    uU        -   A          --gug   a 
 cggc gug agua uucu  GGCAGUGU CUU GCUGGUUGUu     agu u
 |||| ||| |||| ||||  |||||||| ||| ||||||||||     |||  
 guug cac ucgu aagA  CCGUCAUA GAA CGACUAAcga     ucg u
u    -   g    g    UC        U   -          aggaa   a 


Annotation confidence High
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Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context
chr5: 167092491-167092592 [+]

Database links

Mature rno-miR-34a-5p

Accession MIMAT0000815
Description Rattus norvegicus rno-miR-34a-5p mature miRNA
Sequence 20 - UGGCAGUGUCUUAGCUGGUUGU - 41
Evidence experimental
cloned [1-2], SOLiD [3]

Mature rno-miR-34a-3p

Accession MIMAT0017106
Description Rattus norvegicus rno-miR-34a-3p mature miRNA
Sequence 64 - AAUCAGCAAGUAUACUGCCCUA - 85
Evidence experimental
SOLiD [3]

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 14691248
    Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
    "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
    "Proc Natl Acad Sci U S A (2004) 101:360-365

  3. PubMed ID: 20403161
    Small RNA expression and strain specificity in the rat
    Linsen SE, de Wit E, de Bruijn E, Cuppen E
    BMC Genomics (2010) 11:249