Stem-loop ebv-mir-BART2

Accession

MI0001068

Description

Epstein Barr virus ebv-mir-BART2 precursor miRNA

Sequence

acUAUUUUCUGCAUUCGCCCUUGCguguccauuguugcAAGGAGCGAUUUGGAGAAAAUAAA
..((((((((.((.(((((((((((..........))))))).))))..)).))))))))..

Structure

ac        G  -U    -       uguc 
  UAUUUUCU CA  UCGC CCUUGCg    c
  |||||||| ||  |||| |||||||     
  AUAAAAGA GU  AGCG GGAAcgu    a
AA        G  UU    A       uguu 

Annotation confidence Not enough data

Comments

Pfeffer et al. cloned 5 miRNAs from a Burkitt's lymphoma cell line (BL41) infected with the B95-8 strain of Epstein-Barr virus [1]. They were all confirmed by Northern blot. The mature miRNA names reflect cloning frequencies from Landgraf et al. [2], and may differ subtly from previous annotations.

Genome context

HHV507799: 152745-152806 [+]

Clustered miRNAs

13 other miRNAs are < 10 kb from ebv-mir-BART2

Disease association

ebv-mir-BART2 is associated with one or more human diseases in the Human microRNA Disease Database

Mature ebv-miR-BART2-5p

• Accession: MIMAT0001000
• Description: Epstein Barr virus ebv-miR-BART2-5p mature miRNA
• Sequence: 3 - UAUUUUCUGCAUUCGCCCUUGC - 24
• Evidence: experimental ; cloned [1-2], Northern [1]

Mature ebv-miR-BART2-3p

• Accession: MIMAT0004744
• Description: Epstein Barr virus ebv-miR-BART2-3p mature miRNA
• Sequence: 39 - AAGGAGCGAUUUGGAGAAAAUAAA - 62
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15118162
   Identification of virus-encoded microRNAs
   "Pfeffer S, Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T"
   "Science (2004) 304:734-736