Accession
MI0001174
Description
Gallus gallus
gga-let-7c precursor miRNA
Gene family
MIPF0000002;
let-7
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Gga-let-7c is a microRNA (miRNA) that is dominantly expressed in chicken breast muscle libraries [PMC3700833]. It has 26 different isoforms, making it one of the most highly expressed miRNAs [PMC4519947]. Some of the isoforms of gga-let-7c are identical to the reference in miRBase [PMC4519947]. The let-7 family, including gga-let-7c, is abundantly expressed in chicken breast muscle libraries and is among the top 20 most abundant miRNAs [PMC4519947]. In other studies, differentially expressed miRNAs were found in various contexts such as chicken lungs infected with avian influenza virus, A549 cells infected with influenza A virus, mice infected with recombinant influenza A H1N1 virus strains, cynomolgus macaques infected with highly pathogenic H5N1 avian virus, and chicken lung and trachea infected with avian influenza virus [PMC5389138]. In the ovary compared to the testis, gga-let-7a, gga-let-7f and gga-let-7c were down-regulated while gga-miR26a, gga-miR148a and gga-miR451 were up-regulated [PMC3526641].
Literature search
47 open access papers mention gga-let-7c
(330 sentences)
(330 sentences)
Sequence
1074972
reads,
12632
reads per million, 5 experiments
gcauccggguUGAGGUAGUAGGUUGUAUGGUUuagaguuacacccugggaguuaaCUGUACAACCUUCUAGCUUUCCuuggagc
((.((((((..(((.(((.(((((((((((((..((.(..((...))..).))))))))))))))).))).)))..))))))))
((.((((((..(((.(((.(((((((((((((..((.(..((...))..).))))))))))))))).))).)))..))))))))
Structure
a uU G U ua g ua c gc uccggg GAG UAG AGGUUGUAUGGUU ga u ca || |||||| ||| ||| ||||||||||||| || | || c cg agguuC UUC AUC UCCAACAUGUCaa uu a gu - CU G U -- g gg c
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr1: 99018794-99018877 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from gga-let-7c
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Database links
Mature gga-let-7c-5p
| Accession | MIMAT0001104 |
| Description | Gallus gallus gga-let-7c-5p mature miRNA |
| Sequence | 11 - UGAGGUAGUAGGUUGUAUGGUU - 32 |
| Evidence |
experimental
Illumina [2] |
| Database links |
|
| Predicted targets |
|
Mature gga-let-7c-3p
| Accession | MIMAT0026492 |
| Description | Gallus gallus gga-let-7c-3p mature miRNA |
| Sequence | 56 - CUGUACAACCUUCUAGCUUUCC - 77 |
| Evidence |
experimental
Illumina [2] |
References
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