Stem-loop hsa-mir-18b

Accession

MI0001518

Symbol

HGNC: MIR18B

Description

Homo sapiens hsa-mir-18b precursor miRNA mir-17

Gene
family

RF00051; mir-17

Literature search

106 open access papers mention hsa-mir-18b
(268 sentences)

Sequence

234508 reads, 1098 reads per million, 99 experiments

uguguUAAGGUGCAUCUAGUGCAGUUAGugaagcagcuuagaaucuacUGCCCUAAAUGCCCCUUCUGGCa
(((...((((.((((.(((.(((((.((................))))))).))).)))).))))...)))

Structure

   guU    U    C   U     U  ugaagca 
ugu   AAGG GCAU UAG GCAGU AG       g
|||   |||| |||| ||| ||||| ||        
aCG   UUCC CGUA AUC CGUca uc       c
   GUC    C    A   C     -  uaagauu 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chrX: 134170041-134170111 [-]

Clustered miRNAs

5 other miRNAs are < 10 kb from hsa-mir-18b

Disease association

hsa-mir-18b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-18b-5p

• Accession: MIMAT0001412
• Description: Homo sapiens hsa-miR-18b-5p mature miRNA
• Sequence: 6 - UAAGGUGCAUCUAGUGCAGUUAG - 28
• Evidence: experimental ; cloned [2]

Mature hsa-miR-18b-3p

• Accession: MIMAT0004751
• Description: Homo sapiens hsa-miR-18b-3p mature miRNA
• Sequence: 49 - UGCCCUAAAUGCCCCUUCUGGC - 70
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15944709
   c-Myc-regulated microRNAs modulate E2F1 expression
   "O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT"
   "Nature (2005) 435:839-843