Stem-loop sequence mmu-mir-450a-1

Accession

MI0001653 (change log)

Previous IDs

mmu-mir-450;mmu-mir-450-1

Description

Mus musculus miR-450a-1 stem-loop

Gene family

MIPF0000128; mir-450

Literature search

7 open access papers mention mmu-mir-450a-1
(82 sentences)

Stem-loop

   --gaga     u         u     u              ugc 
5'       gauac gagcuguuu ugcga guguuccuaauaug   u
         ||||| ||||||||| ||||| ||||||||||||||   a
3'       cugug uucgauaaa acguu uacaaggguuauau   u
   acauaa     u         u     u              uaa 

Deep sequencing

36553 reads, 109 reads per million, 105 experiments

Confidence

Annotation confidence: high

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Comments

Xie et al. [1] refer to this sequence by the internal identifier MIR238. The sequence is unrelated to C. elegans mir-238 (MI0000313).

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chrX: 53048154-53048244 [-]
• Overlapping transcripts:

  intergenic

Clustered miRNAs

< 10kb from mmu-mir-450a-1

• mmu-mir-322: chrX: 53054255-53054349 [-]
• mmu-mir-503: chrX: 53053984-53054054 [-]
• mmu-mir-351: chrX: 53053255-53053353 [-]
• mmu-mir-542: chrX: 53049403-53049487 [-]
• mmu-mir-450a-2: chrX: 53048299-53048367 [-]
• mmu-mir-450a-1: chrX: 53048154-53048244 [-]
• mmu-mir-450b: chrX: 53047997-53048078 [-]

Database links

• EntrezGene:Mir450-1
• RNAcentral:URS00006AC1CE_10090
• miRBase Tracker:MI0001653

Mature sequence mmu-miR-450a-5p

• Accession: MIMAT0001546
• Previous IDs: mmu-miR-450;mmu-miR-450a-5p;mmu-miR-450a
• Sequence: 18 - uuuugcgauguguuccuaauau - 39
• Deep sequencing: 60635 reads, 102 experiments
• Evidence: experimental; cloned [2], Illumina [3-4]
• Database links:
  • RNAcentral:URS00003E5ECC_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-450a-5p
  • miRDB:mmu-miR-450a-5p
  • microrna.org:mmu-miR-450a-5p

Mature sequence mmu-miR-450a-1-3p

• Accession: MIMAT0017182
• Previous IDs: mmu-miR-450a-1*
• Sequence: 53 - auugggaacauuuugcauaaau - 74
• Deep sequencing: 6237 reads, 98 experiments
• Evidence: experimental; Illumina [4]
• Database links:
  • RNAcentral:URS00004C0723_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-450a-1-3p
  • miRDB:mmu-miR-450a-1-3p

References

1. PMID:15735639 "Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals" Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M Nature. 434:338-345(2005).
2. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
3. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
4. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).