Stem-loop sequence dre-mir-429a

AccessionMI0001720 (change log)
Previous IDsdre-mir-429
DescriptionDanio rerio miR-429 stem-loop
Gene family MIPF0000019; mir-8
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-8/mir-141/mir-200_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The miR-8 microRNA precursor (homologous to miR-141, miR-200, miR-236), is a short non-coding RNA gene involved in gene regulation. miR-8 in Drosophila melanogaster is expressed from the 3' arm of related precursor hairpins (represented here), along with miR-200, miR-236, miR-429 and human and mouse homolog miR-141. Members of this precursor family have now been predicted or experimentally confirmed in a wide range of species. The bounds of the precursors are predicted based on conservation and base pairing and are not generally known. The miR-200 family is highly conserved in bilaterian animals, with miR-8 as the sole homolog in Drosophila. This species has accordingly been used heavily in work looking to uncover the biological function of the miR-200 family. miR-8 has been observed at all developmental stages of the embryo, with a complete absence from cultured S2 cells of D. melanogaster. Its expression has been seen to be strongly upregulated in larvae and this expression then sustained through to adulthood.

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Stem-loop
   cu   u        u -          ug      ug   u 
5'   ugu gauggacg c uuaccagaca  guuaga  uaa a
     ||| |||||||| | ||||||||||  ||||||  |||  
3'   aca cuaccugc g aauggucugu  uaaucu  guu a
   gu   -        c u          ca      gu   c 
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Confidence
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Genome context
Coordinates (GRCz11; GCA_000002035.4) Overlapping transcripts
chr23: 24073815-24073896 [+]
intergenic
Clustered miRNAs
< 10kb from dre-mir-429a
dre-mir-200bchr23: 24072029-24072110 [+]
dre-mir-200achr23: 24072160-24072245 [+]
dre-mir-429achr23: 24073815-24073896 [+]
dre-mir-7149chr23: 24074083-24074155 [+]
Database links

Mature sequence dre-miR-429a

Accession MIMAT0001624
Previous IDsdre-miR-429
Sequence

51 - 

uaauacugucugguaaugccgu

 - 72

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Evidence by similarity; MI0001641
Database links
Predicted targets

References

1
PMID:15891114 "Clustering and conservation patterns of human microRNAs" Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H Nucleic Acids Res. 33:2697-2706(2005).