Stem-loop sequence dre-mir-451

AccessionMI0001732 (change log)
DescriptionDanio rerio miR-451 stem-loop
Gene family MIPF0000148; mir-451
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled Mir-451_microRNA. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology mir-451 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-451 regulates the drug-transporter protein P-glycoprotein, potentially promoting resistance to the chemotherapy drug Paclitaxel.

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Stem-loop
             a    g            a 
5' agaggcggcg aacc uuaccauuacug g
   |||||||||| |||| ||||||||||||  
3' uuuccgucgu uugg aaugguaaugau u
             c    g            u 
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Confidence
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Genome context
Coordinates (GRCz11; GCA_000002035.4) Overlapping transcripts
chr5: 42271971-42272030 [-]
sense
OTTDART00000022480 ; si:ch211-207c6.2-001; exon 2
ENSDART00000137692 ; si:ch211-207c6.2-001; exon 2
Clustered miRNAs
< 10kb from dre-mir-451
dre-mir-144chr5: 42272074-42272162 [-]
dre-mir-451chr5: 42271971-42272030 [-]
Database links

Mature sequence dre-miR-451

Accession MIMAT0001634
Sequence

11 - 

aaaccguuaccauuacugaguu

 - 32

Get sequence
Evidence experimental; cloned [2]
Database links
Predicted targets

References

1
PMID:15891114 "Clustering and conservation patterns of human microRNAs" Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H Nucleic Acids Res. 33:2697-2706(2005).
2
PMID:15937218 "The developmental miRNA profiles of zebrafish as determined by small RNA cloning" Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T Genes Dev. 19:1288-1293(2005).