Stem-loop sequence dre-let-7c-1

AccessionMI0001866
DescriptionDanio rerio let-7c-1 stem-loop
Gene family MIPF0000002; let-7
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled let-7_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.

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Stem-loop
      a ag    u  a      cu   g   u             uag      gc 
5' cug g  ugug gc uccagg  gag uag agguuguaugguu   aauuuu  c
   ||| |  |||| || ||||||  ||| ||| |||||||||||||   ||||||   
3' gac c  acac cg agguuc  uuc auc uccaacaugucaa   uugagg  c
      - ga    u  -      cu   g   u             ---      gu 
Get sequence
Deep sequencing
4290 reads, 1.07e+03 reads per million, 4 experiments
Confidence
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Genome context
Coordinates (Zv9) Overlapping transcripts
15: 29144917-29145023 [+]
sense
OTTDART00000057551 ; zgc:153372-001; intron 10
ENSDART00000099958 ; zgc:153372-001; intron 10
Clustered miRNAs
< 10kb from dre-let-7c-1
dre-mir-99-115: 29144677-29144760 [+]
dre-let-7c-115: 29144917-29145023 [+]
dre-mir-125c15: 29150062-29150146 [+]
Database links

Mature sequence dre-let-7c-5p

Accession MIMAT0001761
Previous IDsdre-let-7c
Sequence

23 - 

ugagguaguagguuguaugguu

 - 44

Get sequence
Deep sequencing4368 reads, 4 experiments
Evidence experimental; cloned [1]

Mature sequence dre-let-7c-3p

Accession MIMAT0031930
Sequence

68 - 

cuguacaaccuucuagcuuucc

 - 89

Get sequence
Deep sequencing3 reads, 1 experiments
Evidence not experimental

References

1
PMID:15937218 "The developmental miRNA profiles of zebrafish as determined by small RNA cloning" Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T Genes Dev. 19:1288-1293(2005).