Stem-loop sequence dre-mir-7a-3

AccessionMI0001879 (change log)
DescriptionDanio rerio miR-7a-3 stem-loop
Gene family MIPF0000022; mir-7
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-7_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

This family represents the microRNA (miRNA) precursor mir-7. This miRNA has been predicted or experimentally confirmed in a wide range of species. miRNAs are transcribed as ~70 nucleotide precursors (modelled here) and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. The involvement of Dicer in miRNA processing suggests a relationship with the phenomenon of RNA interference. Mature miRNA-7 is derived from three microRNA precursors in the human genome, miR-7-1, miR-7-2 and miR-7-3. miRNAs are numbered based on the sequence of the mature RNA. miR-7 is directly regulated by the transcription factor HoxD10. miRNAs are thought to have regulatory roles through complementarity to mRNA. miR-7 is essential for the maintenance of regulatory stability under conditions of environmental flux. It plays an important role in controlling mRNA expression. The miR-7 gene is found in most sequenced Urbilateria species, and the sequence of its mature miRNA product is perfectly conserved from annelids to humans, indicating a strong functional conservation.

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   ugugug          ---------    -   g   u   a    a   au        gaaaauga 
5'       uguguucugc         ccuc ugc gag gga gacu gug  uuuguugu        a
         ||||||||||         |||| ||| ||| ||| |||| |||  ||||||||         
3'       acacgagacg         gggg acg cuc ccu cuga cgc  aaacaaca        c
   ------          uccacaccc    c   a   u   g    -   -c        accaaaaa 
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Genome context
Coordinates (GRCz11; GCA_000002035.4) Overlapping transcripts
chr8: 10205-10324 [+]
ENSDART00000017718 ; fem1c-201; intron 3
Database links

Mature sequence dre-miR-7a

Accession MIMAT0001266
Previous IDsdre-miR-7

28 - 


 - 50

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Evidence experimental; cloned [1]
Database links
Predicted targets


PMID:15937218 "The developmental miRNA profiles of zebrafish as determined by small RNA cloning" Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T Genes Dev. 19:1288-1293(2005).