Stem-loop sequence dre-mir-9-1

DescriptionDanio rerio miR-9-1 stem-loop
Gene family MIPF0000014; mir-9
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-9/mir-79_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The miR-9 microRNA (homologous to miR-79), is a short non-coding RNA gene involved in gene regulation. The mature ~21nt miRNAs are processed from hairpin precursor sequences by the Dicer enzyme. The dominant mature miRNA sequence is processed from the 5' arm of the mir-9 precursor, and from the 3' arm of the mir-79 precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. In vertebrates, miR-9 is highly expressed in the brain, and is suggested to regulate neuronal differentiation. A number of specific targets of miR-9 have been proposed, including the transcription factor REST and its partner CoREST.

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         ggc     uc               g     ---   u 
5' gggguu   uguua  uuugguuaucuagcu uauga   gug u
   ||||||   |||||  ||||||||||||||| |||||   ||| a
3' cccuaa   acaau  aagccaauagaucga auacu   uac u
         -ga     ga               a     ucu   u 
Get sequence
Deep sequencing
5035 reads, 599 reads per million, 4 experiments
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Genome context
Coordinates (Zv9) Overlapping transcripts
16: 31444462-31444548 [+]
OTTDART00000023174 ; si:dkey-235h8.1-001; exon 2
ENSDART00000149569 ; si:dkey-235h8.1-001; exon 2
Database links

Mature sequence dre-miR-9-5p

Accession MIMAT0001769
Previous IDsdre-miR-9

15 - 


 - 37

Get sequence
Deep sequencing26892 reads, 4 experiments
Evidence experimental; cloned [1]
Validated targets

Mature sequence dre-miR-9-3p

Accession MIMAT0003156
Previous IDsdre-miR-9*

55 - 


 - 75

Get sequence
Deep sequencing13102 reads, 4 experiments
Evidence experimental; array [2], in-situ [2]


PMID:15937218 "The developmental miRNA profiles of zebrafish as determined by small RNA cloning" Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T Genes Dev. 19:1288-1293(2005).
PMID:15919954 "MicroRNA expression in zebrafish embryonic development" Wienholds E, Kloosterman WP, Miska E, Alvarez-Saavedra E, Berezikov E, de Bruijn E, Horvitz HR, Kauppinen S, Plasterk RH Science. 309:310-311(2005).