Stem-loop sequence dre-mir-9-6

AccessionMI0001885 (change log)
DescriptionDanio rerio miR-9-6 stem-loop
Gene family MIPF0000014; mir-9
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-9/mir-79_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The miR-9 microRNA (homologous to miR-79), is a short non-coding RNA gene involved in gene regulation. The mature ~21nt miRNAs are processed from hairpin precursor sequences by the Dicer enzyme. The dominant mature miRNA sequence is processed from the 5' arm of the mir-9 precursor, and from the 3' arm of the mir-79 precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. In vertebrates, miR-9 is highly expressed in the brain, and is suggested to regulate neuronal differentiation. A number of specific targets of miR-9 have been proposed, including the transcription factor REST and its partner CoREST.

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Stem-loop
        ua   g   uc               g      u  uu 
5' ggagg  guu cua  uuugguuaucuagcu uaugag gu  a
   |||||  ||| |||  ||||||||||||||| |||||| ||   
3' ccucc  uaa gau  aagccaauagaucga auacuu cg  u
        ug   a   ga               a      c  uc 
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Confidence
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Genome context
Coordinates (GRCz11; GCA_000002035.4) Overlapping transcripts
chr7: 14379544-14379631 [-]
intergenic
Database links

Mature sequence dre-miR-9-5p

Accession MIMAT0001769
Previous IDsdre-miR-9
Sequence

15 - 

ucuuugguuaucuagcuguauga

 - 37

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Evidence experimental; cloned [1]
Database links
Predicted targets

Mature sequence dre-miR-9-3p

Accession MIMAT0003156
Previous IDsdre-miR-9*
Sequence

55 - 

uaaagcuagauaaccgaaagu

 - 75

Get sequence
Evidence experimental; array [2], in-situ [2]
Database links

References

1
PMID:15937218 "The developmental miRNA profiles of zebrafish as determined by small RNA cloning" Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T Genes Dev. 19:1288-1293(2005).
2
PMID:15919954 "MicroRNA expression in zebrafish embryonic development" Wienholds E, Kloosterman WP, Miska E, Alvarez-Saavedra E, Berezikov E, de Bruijn E, Horvitz HR, Kauppinen S, Plasterk RH Science. 309:310-311(2005).