Stem-loop sequence dre-mir-21-2

AccessionMI0001909 (change log)
DescriptionDanio rerio miR-21-2 stem-loop
Gene family MIPF0000060; mir-21
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled MIRN21. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene. MIRN21 was one of the first mammalian microRNAs identified. The mature miR-21 sequence is strongly conserved throughout evolution. The human microRNA-21 gene is located on plus strand of chromosome 17q23.2 (55273409–55273480) within a coding gene TMEM49 (also called vacuole membrane protein). Despite being located in intronic regions of a coding gene in the direction of transcription, it has its own promoter regions and forms a ~3433-nt long primary transcript of miR-21 (known as pri-miR-21) which is independently transcribed. The stem–loop recursor of miR-21(pre-miR-21) resides between nucleotides 2445 and 2516 of pri-miR-21.

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           a   ---aa    -u   uuuc     ug        c      g     g uuug 
5' agacagac gua     agug  ccc    uguca  uagcuuau agacug uguug c    a
   |||||||| |||     ||||  |||    |||||  |||||||| |||||| ||||| |    g
3' uuuguuug cau     uuau  ggg    acagu  gucggaua ucugac acaac g    u
           g   gcagc    uc   uuuu     cu        a      g     g uuuu 
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Genome context
Coordinates (GRCz11; GCA_000002035.4) Overlapping transcripts
chr15: 17373789-17373915 [+]
Database links

Mature sequence dre-miR-21

Accession MIMAT0001787

34 - 


 - 56

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Evidence experimental; cloned [1]
Database links
Predicted targets


PMID:15937218 "The developmental miRNA profiles of zebrafish as determined by small RNA cloning" Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T Genes Dev. 19:1288-1293(2005).