Stem-loop sequence dre-mir-107a

AccessionMI0001963
Previous IDsdre-mir-107-1;dre-mir-107
DescriptionDanio rerio miR-107 stem-loop
Gene family MIPF0000024; mir-103
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-103/107_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The miR-103 microRNA precursor (homologous to miR-107), is a short non-coding RNA gene involved in gene regulation. miR-103 and miR-107 have now been predicted or experimentally confirmed in human. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. mir-103 and mir-107 were noted as being upregulated in obese mice and were subsequently found to have a key role in insulin sensitivity. This led to a suggestion that these microRNAs represent potential targets for the treatment of type 2 diabetes. mir-103 has also been linked with chronic pain and intestinal cell proliferation.

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Stem-loop
   -----  u       c   --   u  u          u    ugg a 
5'      uc gugugcu uga  gcu cu uacaguguug cuug   c u
        || ||||||| |||  ||| || |||||||||| ||||   | g
3'      ag cacacga acu  cgg ga auguuacgac gaac   g g
   cgaca  u       c   au   -  c          -    -ua a 
Get sequence
Deep sequencing
5418 reads, 691 reads per million, 4 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?
Genome context
Coordinates (Zv9) Overlapping transcripts
12: 18027645-18027733 [+]
sense
OTTDART00000036913 ; pank1b-001; intron 5
ENSDART00000020824 ; pank1b-001; intron 5
Database links

Mature sequence dre-miR-107a-5p

Accession MIMAT0031959
Sequence

14 - 

agcuucuuuacaguguugucuug

 - 36

Get sequence
Deep sequencing281 reads, 4 experiments
Evidence not experimental

Mature sequence dre-miR-107a-3p

Accession MIMAT0001817
Previous IDsdre-miR-107a
Sequence

51 - 

agcagcauuguacagggcuauca

 - 73

Get sequence
Deep sequencing4498 reads, 4 experiments
Evidence by similarity; MI0000114

References

1
PMID:15937218 "The developmental miRNA profiles of zebrafish as determined by small RNA cloning" Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T Genes Dev. 19:1288-1293(2005).