Stem-loop sequence dre-mir-133c

AccessionMI0001995 (change log)
DescriptionDanio rerio miR-133c stem-loop
Gene family MIPF0000029; mir-133
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-133_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

mir-133 is a type of non-coding RNA called a microRNA that was first experimentally characterised in mice. Homologues have since been discovered in several other species including invertebrates such as the fruitfly Drosophila melanogaster. Each species often encodes multiple microRNAs with identical or similar mature sequence. For example, in the human genome there are three known miR-133 genes: miR-133a-1, miR-133a-2 and miR-133b found on chromosomes 18, 20 and 6 respectively. The mature sequence is excised from the 3' arm of the hairpin. miR-133 is expressed in muscle tissue and appears to repress the expression of non-muscle genes.

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Stem-loop
   -gaaa      u    u      aa  c  a     gu ggg  u 
5'      cacggc uagu gcuggu  aa gg accaa  c   ug u
        |||||| |||| ||||||  || || |||||  |   ||  
3'      gugccg guca cgacca  uu cc ugguu  g   gc u
   cuuaa      c    u      ac  u  c     ug aga  g 
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Confidence
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Genome context
Coordinates (GRCz11; GCA_000002035.4) Overlapping transcripts
chr17: 5962975-5963065 [-]
intergenic
Clustered miRNAs
< 10kb from dre-mir-133c
dre-mir-206-2chr17: 5967238-5967346 [-]
dre-mir-133cchr17: 5962975-5963065 [-]
Database links

Mature sequence dre-miR-133c-5p

Accession MIMAT0031971
Sequence

17 - 

gcugguaaaacggaaccaaguc

 - 38

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Evidence not experimental
Database links

Mature sequence dre-miR-133c-3p

Accession MIMAT0001832
Previous IDsdre-miR-133c
Sequence

55 - 

uuuggucccuuucaaccagcua

 - 76

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Evidence experimental; cloned [1]
Database links
Predicted targets

References

1
PMID:15937218 "The developmental miRNA profiles of zebrafish as determined by small RNA cloning" Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T Genes Dev. 19:1288-1293(2005).