Stem-loop sequence dre-mir-143

AccessionMI0002007 (change log)
DescriptionDanio rerio miR-143 stem-loop
Gene family MIPF0000094; mir-143
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled Mir-143. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology mir-143 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by a several mechanisms. mir–143 is highly conserved in vertebrates. mir-143 is thought be involved in cardiac morphogenesis but has also been implicated in cancer.

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     u  -     --c    gg    c g         g      u  -  aa 
5' ga cu acagu   gucu  cccg g ugcagugcu caucuc gg uc  c
   || || |||||   ||||  |||| | ||||||||| |||||| || ||   
3' cu ga uguca   cagg  gggc c augucacga guagag cu ag  u
     c  c     caa    -a    u g         a      u  g  gg 
Get sequence
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The cloned mature miR-143 sequence always appears to be 22nt in length, modified by the addition of a 3' U residue not found in the genomic sequence [1].

Genome context
Coordinates (GRCz11; GCA_000002035.4) Overlapping transcripts
chr14: 38742313-38742411 [+]
KZ115462.1: 17707-17805 [+]
Clustered miRNAs
< 10kb from dre-mir-143
dre-mir-143chr14: 38742313-38742411 [+]
dre-mir-145chr14: 38743941-38744053 [+]
Database links

Mature sequence dre-miR-143

Accession MIMAT0001840

57 - 


 - 77

Get sequence
Evidence experimental; cloned [1]
Predicted targets


PMID:15937218 "The developmental miRNA profiles of zebrafish as determined by small RNA cloning" Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T Genes Dev. 19:1288-1293(2005).