Dead miRNA entry

miRNA accession:
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The sequences previously named mir-143-1 and mir-143-2 map to the same locus in the GRCz10 genome assembly. The entries are therefore merged.

Previous miRNA entry

Stem-loop sequence dre-mir-143-2

AccessionMI0002008 (change log)
DescriptionDanio rerio miR-143-2 stem-loop
Gene family MIPF0000094; mir-143
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled Mir-143. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology mir-143 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by a several mechanisms. mir–143 is highly conserved in vertebrates. mir-143 is thought be involved in cardiac morphogenesis but has also been implicated in cancer.

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     u  -     --c    gg    c g         g      u  -  aa 
5' ga cu acagu   gucu  cccg g ugcagugcu caucuc gg uc  c
   || || |||||   ||||  |||| | ||||||||| |||||| || ||   
3' cu ga uguca   cagg  gggc c augucacga guagag cu ag  u
     c  c     caa    -a    u g         a      u  g  gg 
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The cloned mature miR-143 sequence always appears to be 22nt in length, modified by the addition of a 3' U residue not found in the genomic sequence [1].

Database links

Mature sequence dre-miR-143

Accession MIMAT0001840

57 - 


 - 77

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Evidence experimental; cloned [1]
Predicted targets


PMID:15937218 "The developmental miRNA profiles of zebrafish as determined by small RNA cloning" Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T Genes Dev. 19:1288-1293(2005).