Stem-loop sequence dre-mir-218a-2

DescriptionDanio rerio miR-218a-2 stem-loop
Gene family MIPF0000026; mir-218
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-218_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

miR-218 microRNA precursor is a small non-coding RNA that regulates gene expression by antisense binding. miR-218 appears to be a vertebrate specific microRNA and has now been predicted and experimentally confirmed in a wide range of vertebrate species. The extents of the hairpin precursors are not known. In this case the mature sequence in excised from the 5'arm of the hairpin. miR-218, along with miR-585, has been found to be silenced by DNA methylation in oral squamous cell carcinoma. It is also downregulated in Nasopharyngeal carcinoma, with artificially-induced expression serving to slow tumour growth. miR-218 has also been found to have tumour suppressing qualities in bladder cancer cells.

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        gu     uuu         cu        ---    gca 
5' gcggg  uuucc   gugcuugau  aaccaugu   gguu   g
   |||||  |||||   |||||||||  ||||||||   ||||   a
3' cguuc  gaagg   cacgaacug  uugguaca   ucag   c
        ug     uac         uc        uaa    acu 
Get sequence
Deep sequencing
1109 reads, 100 reads per million, 4 experiments
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Genome context
Coordinates (Zv9) Overlapping transcripts
1: 22640972-22641059 [+]
OTTDART00000041849 ; slit2-001; intron 14
ENSDART00000007531 ; slit2-001; intron 14
Database links

Mature sequence dre-miR-218a

Accession MIMAT0001868

14 - 


 - 35

Get sequence
Deep sequencing1397 reads, 4 experiments
Evidence experimental; cloned [1]


PMID:15937218 "The developmental miRNA profiles of zebrafish as determined by small RNA cloning" Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T Genes Dev. 19:1288-1293(2005).