| Community annotation |
This text is a summary paragraph taken from the Wikipedia entry entitled mir-218_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...
The text in this section is taken from the free, online
encyclopedia, Wikipedia. Anyone can edit a Wikipedia page. We hope
that experts on particular microRNA sequences will use the links to
Wikipedia below to edit the annotation of individual microRNAs, to add
information about function, evolution, discovery, and literature
references, for example. Any changes that you make will be visible in
Wikipedia immediately, and in miRBase within 24 hours.
Editing Wikipedia entries is straightforward. If you haven't
edited a page before, you might like to take a look at the following
Wikipedia help pages:
You can also create new pages at Wikipedia about microRNA families
that do not currently have specific entries there. Please let us know
if you do, so we can incorporate your annotation into miRBase, and
create the appropriate links from miRBase entries to the relevant
Wikipedia pages.
Please note, we're not responsible for the content of Wikipedia pages.
You can read more about miRBase, Wikipedia and community annotation on this blog post.
Please email us for
help or with comments about this community annotation initiative.
miR-218 microRNA precursor is a small non-coding RNA that regulates gene expression by antisense binding.
miR-218 appears to be a vertebrate specific microRNA and has now been predicted and experimentally confirmed in a wide range of vertebrate species. The extents of the hairpin precursors are not known. In this case the mature sequence in excised from the 5'arm of the hairpin.
miR-218, along with miR-585, has been found to be silenced by DNA methylation in oral squamous cell carcinoma. It is also downregulated in Nasopharyngeal carcinoma, with artificially-induced expression serving to slow tumour growth. miR-218 has also been found to have tumour suppressing qualities in bladder cancer cells.
Show Wikipedia entry
View @ Wikipedia
Edit Wikipedia entry
miR-218 microRNA precursor is a small non-coding RNA that regulates gene expression by antisense binding.
miR-218 appears to be a vertebrate specific microRNA and has now been predicted and experimentally confirmed in a wide range of vertebrate species.[1] The extents of the hairpin precursors are not known. In this case the mature sequence in excised from the 5'arm of the hairpin.
miR-218, along with miR-585, has been found to be silenced by DNA methylation in oral squamous cell carcinoma.[2] It is also downregulated in Nasopharyngeal carcinoma, with artificially-induced expression serving to slow tumour growth.[3] miR-218 has also been found to have tumour suppressing qualities in bladder cancer cells.[4]
References
- ^ "miRNA gene family: mir-218". mirBASE. The University of Manchester.
- ^ Uesugi, A; Kozaki, K; Tsuruta, T; Furuta, M; Morita, K; Imoto, I; Omura, K; Inazawa, J (Sep 1, 2011). "The Tumor Suppressive MicroRNA miR-218 Targets the mTOR Component Rictor and Inhibits AKT Phosphorylation in Oral Cancer.". Cancer Research 71 (17): 5765–78. doi:10.1158/0008-5472.CAN-11-0368. PMID 21795477.
- ^ Alajez, NM; Lenarduzzi, M, Ito, E, Hui, AB, Shi, W, Bruce, J, Yue, S, Huang, SH, Xu, W, Waldron, J, O'Sullivan, B, Liu, FF (Mar 15, 2011). "MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway.". Cancer Research 71 (6): 2381–91. doi:10.1158/0008-5472.CAN-10-2754. PMID 21385904.
- ^ Tatarano, S; Chiyomaru, T, Kawakami, K, Enokida, H, Yoshino, H, Hidaka, H, Yamasaki, T, Kawahara, K, Nishiyama, K, Seki, N, Nakagawa, M (July 2011). "miR-218 on the genomic loss region of chromosome 4p15.31 functions as a tumor suppressor in bladder cancer.". International journal of oncology 39 (1): 13–21. doi:10.3892/ijo.2011.1012. PMID 21519788.
External links
|
