Stem-loop sequence dre-mir-301b

AccessionMI0002061 (change log)
DescriptionDanio rerio miR-301b stem-loop
Gene family MIPF0000034; mir-130
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-130_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse (MI0000156, MI0000408), and in human (MI0000448, MI0000748). miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma. It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells.

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         ugu   uu       ---        a  -  acc 
5' aagguc   ugc  ugacgau   guugcacu cu ga   a
   ||||||   |||  |||||||   |||||||| || ||   u
3' uuucgg   acg  acuguua   uaacguga ga cu   c
         cuu   uu       uga        c  a  aau 
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Genome context
Coordinates (GRCz11; GCA_000002035.4) Overlapping transcripts
chr5: 13289353-13289433 [+]
Clustered miRNAs
< 10kb from dre-mir-301b
dre-mir-130c-2chr5: 13288828-13288908 [+]
dre-mir-301bchr5: 13289353-13289433 [+]
dre-mir-454bchr5: 13296307-13296422 [+]
dre-mir-130bchr5: 13299331-13299414 [+]
Database links

Mature sequence dre-miR-301b-5p

Accession MIMAT0031990

11 - 


 - 31

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Evidence not experimental
Database links

Mature sequence dre-miR-301b-3p

Accession MIMAT0001871
Previous IDsdre-miR-301b

49 - 


 - 70

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Evidence experimental; cloned [1]
Predicted targets


PMID:15937218 "The developmental miRNA profiles of zebrafish as determined by small RNA cloning" Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T Genes Dev. 19:1288-1293(2005).