Stem-loop sequence dre-mir-301c

AccessionMI0002062 (change log)
DescriptionDanio rerio miR-301c stem-loop
Gene family MIPF0000034; mir-130
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-130_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse (MI0000156, MI0000408), and in human (MI0000448, MI0000748). miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma. It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells.

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   u    uc  c    c       ---        a   uacca 
5'  gagg  ag ugcu ugacgau   guugcacu cug     u
    ||||  || |||| |||||||   |||||||| |||      
3'  cucc  uu acga acuguua   uaacguga gau     c
   u    ga  u    u       uga        c   cuuac 
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Genome context
Coordinates (GRCz11; GCA_000002035.4) Overlapping transcripts
chr10: 17454490-17454572 [+]
Clustered miRNAs
< 10kb from dre-mir-301c
dre-mir-130c-1chr10: 17453363-17453503 [+]
dre-mir-301cchr10: 17454490-17454572 [+]
Database links

Mature sequence dre-miR-301c-5p

Accession MIMAT0031991

12 - 


 - 32

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Evidence not experimental
Database links

Mature sequence dre-miR-301c-3p

Accession MIMAT0001872
Previous IDsdre-miR-301c

50 - 


 - 71

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Evidence experimental; cloned [1]
Database links
Predicted targets


PMID:15937218 "The developmental miRNA profiles of zebrafish as determined by small RNA cloning" Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T Genes Dev. 19:1288-1293(2005).