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miR-338 is a family of brain-specific microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.
miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase (AATK). It has been predicted that it may downregulate genes which have a downstream negative effect on AATK expression.
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miR-338 is a family of brain-specific microRNA precursors found in mammals, including humans.[1] The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[2] This sequence then associates with RISC which effects RNA interference.[3]
miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase (AATK). It has been predicted that it may downregulate genes which have a downstream negative effect on AATK expression.[4]
Function
miR-338 is a brain-specific miRNA which regulates the expression of cytochrome c oxidase IV (COX4).[1][5] The mature miR-338 miRNA sequence is complementary to a short section of the 3' untranslated region of COX4 mRNA. This mRNA sequence is presented atop a stem-loop structure, indicating it is accessible to miRNA processing.[5]
Applications
miR-338 is dysregulated in neuroblastoma, and could potentially be implemented as a biomarker or future therapeutic agent.[6] miR-338 has also been linked with hepatocellular carcinoma, and a large-scale diagnostic test has been suggested involving measurement of miR-338 expression in tissue samples.[7] Furthermore, miR-338 is one of seven microRNAs whose expression profiles can be combined to give a prediction of the probability of survival of a patient with gastric cancer.[8]
References
- ^ a b Aschrafi, A; Schwechter, AD, Mameza, MG, Natera-Naranjo, O, Gioio, AE, Kaplan, BB (2008-11-19). "MicroRNA-338 regulates local cytochrome c oxidase IV mRNA levels and oxidative phosphorylation in the axons of sympathetic neurons". The Journal of neuroscience : the official journal of the Society for Neuroscience 28 (47): 12581–90. doi:10.1523/JNEUROSCI.3338-08.2008. PMC 3496265. PMID 19020050.
- ^ Ambros, V (2001-12-28). "microRNAs: tiny regulators with great potential". Cell 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- ^ Gregory, RI; Chendrimada, TP, Cooch, N, Shiekhattar, R (2005-11-18). "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing". Cell 123 (4): 631–40. doi:10.1016/j.cell.2005.10.022. PMID 16271387.
- ^ Barik, S (Sep 2008). "An intronic microRNA silences genes that are functionally antagonistic to its host gene". Nucleic Acids Research 36 (16): 5232–41. doi:10.1093/nar/gkn513. PMC 2532712. PMID 18684991.
- ^ a b Kaplan, BB; Gioio, AE, Hillefors, M, Aschrafi, A (2009). "Axonal protein synthesis and the regulation of local mitochondrial function". Results and problems in cell differentiation. Results and Problems in Cell Differentiation 48: 225–42. doi:10.1007/400_2009_1. ISBN 978-3-642-03018-5. PMC 2786086. PMID 19343315.
- ^ Ragusa, M; Majorana, A, Banelli, B, Barbagallo, D, Statello, L, Casciano, I, Guglielmino, MR, Duro, LR, Scalia, M, Magro, G, Di Pietro, C, Romani, M, Purrello, M (Oct 2010). "MIR152, MIR200B, and MIR338, human positional and functional neuroblastoma candidates, are involved in neuroblast differentiation and apoptosis". Journal of molecular medicine (Berlin, Germany) 88 (10): 1041–53. doi:10.1007/s00109-010-0643-0. PMID 20574809.
- ^ Huang, XH; Wang, Q, Chen, JS, Fu, XH, Chen, XL, Chen, LZ, Li, W, Bi, J, Zhang, LJ, Fu, Q, Zeng, WT, Cao, LQ, Tan, HX, Su, Q (Aug 2009). "Bead-based microarray analysis of microRNA expression in hepatocellular carcinoma: miR-338 is downregulated". Hepatology research : the official journal of the Japan Society of Hepatology 39 (8): 786–94. doi:10.1111/j.1872-034X.2009.00502.x. PMID 19473441.
- ^ Li, X; Zhang, Y; Zhang, Y; Ding, J; Wu, K; Fan, D (May 2010). "Survival prediction of gastric cancer by a seven-microRNA signature". Gut 59 (5): 579–85. doi:10.1136/gut.2008.175497. PMID 19951901.
Further reading
- He, QY; Peng, GP, Liu, WX, Luo, BY (Nov 2010). "[Interaction of microRNA-338 and its potential targeting protein eiF4E3]". Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 39 (6): 583–8. PMID 21166051. (Chinese)
- Saba, R; Goodman, CD, Huzarewich, RL, Robertson, C, Booth, SA (2008). "A miRNA signature of prion induced neurodegeneration". In Akbarian, Schahram. PLoS ONE 3 (11): e3652. doi:10.1371/journal.pone.0003652. PMC 2575400. PMID 18987751.
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