Stem-loop kshv-miR-K12-2

Accession

MI0002476

Description

Kaposi sarcoma-associated herpesvirus kshv-miR-K12-2 precursor miRNA

Sequence

gggucuacuucgcuAACUGUAGUCCGGGUCGAUCUGagccauugaagcaagcuuccaGAUCUUCCAGGGCUAGAGCUGccgcggugacacc
(((((.(((.((.((.((.((((((.((..(((((((((...........)))..))))))..)).)))))).)).)).)).)))))).))

Structure

  -   u   u  c  A  G      G  UC      --   cauu 
gg guc acu cg uA CU UAGUCC GG  GAUCUG  agc    g
|| ||| ||| || || || |||||| ||  ||||||  |||    a
cc cag ugg gc GU GA AUCGGG CC  CUAGac  ucg    a
  a   -   c  c  C  G      A  UU      cu   aacg 

Annotation confidence Not enough data

Comments

Cai et al. define the likely miRNA primary transcripts in [2].

Genome context

KSU75698: 121674-121764 [-]

Clustered miRNAs

11 other miRNAs are < 10 kb from kshv-miR-K12-2

Mature kshv-miR-K12-2-5p

• Accession: MIMAT0002183
• Description: Kaposi sarcoma-associated herpesvirus kshv-miR-K12-2-5p mature miRNA
• Sequence: 15 - AACUGUAGUCCGGGUCGAUCUG - 36
• Evidence: experimental ; cloned [1], Illumina [3], SOLiD [4]

Mature kshv-miR-K12-2-3p

• Accession: MIMAT0015215
• Description: Kaposi sarcoma-associated herpesvirus kshv-miR-K12-2-3p mature miRNA
• Sequence: 58 - GAUCUUCCAGGGCUAGAGCUG - 78
• Evidence: experimental ; Illumina [3], SOLiD [4]

References

1. PubMed ID: 15800047
   Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
   "Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR"
   "Proc Natl Acad Sci U S A (2005) 102:5570-5575


2. PubMed ID: 16474131
   Transcriptional origin of Kaposi's sarcoma-associated herpesvirus microRNAs
   "Cai X, Cullen BR"
   "J Virol (2006) 80:2234-2242


3. PubMed ID: 19889781
   In-depth analysis of Kaposi's sarcoma-associated herpesvirus microRNA expression provides insights into the mammalian microRNA-processing machinery
   "Umbach JL, Cullen BR"
   "J Virol (2010) 84:695-703


4. PubMed ID: 20566670
   Small RNA profiling reveals antisense transcription throughout the KSHV genome and novel small RNAs
   "Lin YT, Kincaid RP, Arasappan D, Dowd SE, Hunicke-Smith SP, Sullivan CS"
   "RNA (2010) 16:1540-1558