miRBase entry: mml-mir-181c

Stem-loop mml-mir-181c


Accession
MI0002811
Description
Macaca mulatta mml-mir-181c precursor miRNA
Gene family
MIPF0000007; mir-181

Literature search
3 open access papers mention mml-mir-181c
(4 sentences)

Sequence

84264 reads, 508 reads per million, 9 experiments
cggagaauuugccaaggguuugggggAACAUUCAACCUGUCGGUGAGUuugggcagcucaggcaaaCCAUCGACCGUUGAGUGGACCcugagaccuggacuugccauccu
.(((......((((..(((((.((((..((((((((..(((((((.(((((...........)))))))))))).))))))))..)))).)))))))).)......))).

Structure
c   gaauuu -   ag     g    AA        CU       A     ggca 
 gga      g cca  gguuu gggg  CAUUCAAC  GUCGGUG GUuug    g
 |||      | |||  ||||| ||||  ||||||||  ||||||| |||||    c
 ccu      c ggu  ccaga ucCC  GUGAGUUG  CAGCUAC Caaac    u
u   accguu a   --     g    AG        -C       -     ggac 


Annotation confidence High
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Comments
Berezikov et al. used primers designed from human miRNA gene flanking sequence to amplify miRNA precursor regions in primates [2]. The expression of this mature miRNA was validated by Miska et al [1].

Genome context
chr19: 13878531-13878640 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from mml-mir-181c
Name Accession Chromosome Start End Strand Confidence




Database links

Mature mml-miR-181c-5p

Accession MIMAT0002509
Description Macaca mulatta mml-miR-181c-5p mature miRNA
Sequence 27 - AACAUUCAACCUGUCGGUGAGU - 48
Evidence experimental
cloned [1], Illumina [3]
Database links
Predicted targets

Mature mml-miR-181c-3p

Accession MIMAT0026587
Description Macaca mulatta mml-miR-181c-3p mature miRNA
Sequence 67 - CCAUCGACCGUUGAGUGGACC - 87
Evidence experimental
Illumina [3]

References

  1. PubMed ID: 15345052
    Microarray analysis of microRNA expression in the developing mammalian brain
    Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
    Genome Biol (2004) 5:R68

  2. PubMed ID: 15652478
    Phylogenetic shadowing and computational identification of human microRNA genes
    "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
    "Cell (2005) 120:21-24

  3. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45