miRBase entry: hsa-mir-496

Stem-loop hsa-mir-496


Accession
MI0003136
Symbol
HGNC: MIR496
Description
Homo sapiens hsa-mir-496 precursor miRNA
Gene family
MIPF0000018; mir-154

Literature search
15 open access papers mention hsa-mir-496
(120 sentences)

Sequence

405 reads, 25 reads per million, 37 experiments
cccaagucagguacucgaauggagguuguccaugguguguucauuuuauuuaugaUGAGUAUUACAUGGCCAAUCUCcuuucgguacucaauucuucuuggg
((((((...(((((.((((.((((((((.(((((..(((((((((........)))))))))..))))).)))))))).)))))))))........))))))

Structure
      -----uca     u    u        u     gu         uua 
cccaag        gguac cgaa ggagguug ccaug  guguucauu   u
||||||        ||||| |||| |||||||| |||||  |||||||||    
ggguuc        ucaug gcuu cCUCUAAC GGUAC  UAUGAGUag   u
      uucuuaac     -    u        C     AU         uau 


Annotation confidence Not enough data
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations. miR-496 cloned in [2] has a 1 nt 3' extension (U), which is incompatible with the genome sequence.

Genome context
chr14: 101060573-101060674 [+]
Clustered miRNAs
14 other miRNAs are < 10 kb from hsa-mir-496
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-496 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-496

Accession MIMAT0002818
Description Homo sapiens hsa-miR-496 mature miRNA
Sequence 56 - UGAGUAUUACAUGGCCAAUCUC - 77
Evidence experimental
array-cloned [1], cloned [2]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770