Accession
MI0003160
Symbol
HGNC:
MIR524
Description
Homo sapiens
hsa-mir-524 precursor miRNA mir-515
Gene
family?
family?
RF00639;
mir-515
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR524 is a microRNA gene that is part of the C19MC miRNA cluster, which includes a total of 46 miRNA genes [PMC6193703]. This gene plays a significant role in the regulation of various pathways, as its downregulation has been associated with the activation of the TGF-β, Notch, and Hippo pathways due to an overexpressed EGFR/myc axis in breast invasive carcinoma [PMC9966483]. Additionally, MIR524 has been identified as a regulator of MXD1 and is influenced by copy number variations (CNVs) along with other microRNAs such as mir1283 and mir520d [PMC3938728]. In liver hepatocellular carcinoma (LIHC), MIR524 expression was analyzed as part of an integrated dataset that combined miRNA-seq and RNA-seq data to provide insights into its role in cancer [PMC7378193]. Furthermore, EGFR has been shown to negatively regulate MIR524 by recruiting repressive histone modifiers to its promoter region, which results in reduced production of pri-miR-524 [PMC7766154].
Literature search
16 open access papers mention hsa-mir-524
(254 sentences)
(254 sentences)
Sequence
59
reads,
2
reads per million, 15 experiments
ucucaugcugugaccCUACAAAGGGAAGCACUUUCUCuuguccaaaggaaaaGAAGGCGCUUCCCUUUGGAGUguuacgguuugaga
(((((.((((((((.((.(((((((((((.((((((....(((...)))..)))))).))))))))))).)).)))))))).)))))
(((((.((((((((.((.(((((((((((.((((((....(((...)))..)))))).))))))))))).)).)))))))).)))))
Structure
u c A A Cuug a
ucuca gcugugac CU CAAAGGGAAGC CUUUCU ucc
||||| |||||||| || ||||||||||| |||||| ||| a
agagu uggcauug GA GUUUCCCUUCG GGAAGa agg
u U G C --aa a
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr19: 53711002-53711088 [+]
Clustered miRNAs
9 other miRNAs are < 10 kb from hsa-mir-524
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-524 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-524-5p
| Accession | MIMAT0002849 |
| Description | Homo sapiens hsa-miR-524-5p mature miRNA |
| Sequence | 16 - CUACAAAGGGAAGCACUUUCUC - 37 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-524-3p
| Accession | MIMAT0002850 |
| Description | Homo sapiens hsa-miR-524-3p mature miRNA |
| Sequence | 53 - GAAGGCGCUUCCCUUUGGAGU - 73 |
| Evidence |
experimental
array-cloned [1] |
References
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