Accession
MI0003185
Symbol
HGNC:
MIR501
Description
Homo sapiens
hsa-mir-501 precursor miRNA
Gene family
MIPF0000139;
mir-500
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR501 is a microRNA that has been found to be elevated in plasma in cases of community-acquired pneumonia (CAP), along with other miRNAs such as MIR100, MIR99A, MIR483, MIR141, MIR378C, and MIR193B [PMC8358855]. In wheat, sequencing efforts have identified 58 wheat miRNAs, including 23 novel ones such as MIR501 [PMC5360763]. In a study on schizophrenia, two single-nucleotide polymorphisms upstream of MIR501 and two ultrarare protein-altering variants in its host gene CLCN5 were found to be associated with the disorder [PMC9390987]. The function of miR-501-3p in schizophrenia was investigated using a mouse model with the knockout of the MIR501 gene [PMC9390987]. The human counterpart of mouse MIR501 is located on chromosome Xp11.23 within the CLCN5 gene [PMC9390987]. MiR-501-3p has been shown to be highly expressed in multiple tissues and specific neuronal types [PMC9390987]. The role of miR-501-3p in the pathophysiology of schizophrenia is still being investigated [PMC9390987]. MiR-501 is part of a cluster that includes other microRNAs such as miR532 and miR362 [PMC4241533]. MiR500A is also part of this cluster and has been associated with different cancer types [PMC8253104]. In addition to its role in schizophrenia, miR-501 has also been implicated in synaptic plasticity regulation and periodontitis pathogenesis [PMC4783348] [PMC9314012].
Literature search
35 open access papers mention hsa-mir-501
(59 sentences)
(59 sentences)
Sequence
9875
reads,
179
reads per million, 128 experiments
gcucuuccucucuAAUCCUUUGUCCCUGGGUGAGAgugcuuucugaaugcAAUGCACCCGGGCAAGGAUUCUgagagggugagc
((((.(((((((.(((((((.(.(((.(((((....(((.........)))...))))))))))))))))..))))))).))))
((((.(((((((.(((((((.(.(((.(((((....(((.........)))...))))))))))))))))..))))))).))))
Structure
u -u U U U AGAg uuu
gcuc uccucuc AAUCCUU G CCC GGGUG ugc c
|||| ||||||| ||||||| | ||| ||||| ||| u
cgag gggagag UUAGGAA C GGG CCCAC Acg g
u UC - - - -GUA uaa
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chrX: 50009722-50009805 [+]
Clustered miRNAs
7 other miRNAs are < 10 kb from hsa-mir-501
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-501 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-501-5p
| Accession | MIMAT0002872 |
| Description | Homo sapiens hsa-miR-501-5p mature miRNA |
| Sequence | 14 - AAUCCUUUGUCCCUGGGUGAGA - 35 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-501-3p
| Accession | MIMAT0004774 |
| Description | Homo sapiens hsa-miR-501-3p mature miRNA |
| Sequence | 51 - AAUGCACCCGGGCAAGGAUUCU - 72 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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